Nicotinate-nucleotide pyrophosphorylase - Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Nicotinate-nucleotide pyrophosphorylase EMBL AAL82028.1

Gene names

Ordered Locus Names:

PF1904

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Metal-binding PDB 2I14 Zinc PDB 2I14
Technical term	3D-structure PDB 2I14 Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: InterPro nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

178

1

Zinc 1; via tele nitrogen PDB 2I14

Metal binding

209

1

Zinc 1 PDB 2I14

Metal binding

235

1

Zinc 1 PDB 2I14

Metal binding

327

1

Zinc 2 PDB 2I14

Metal binding

331

1

Zinc 2; via pros nitrogen PDB 2I14

Metal binding

344

1

Zinc 2 PDB 2I14

Metal binding

347

1

Zinc 2 PDB 2I14

Sequences

Sequence

Length

Mass (Da)

Tools

Q8TZS9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 9399CF21D15FE12A
Show »

FASTA

389

43,368

        10         20         30         40         50         60 
MKRFYIANED EIKAGKTTDV YFLRTKKILE VKNIRKKVLA DVTTTSLPNN WRWGVLVGVE 

        70         80         90        100        110        120 
EVAKLLEGIP VNVYAMPEGT IFHPYEPVLQ IEGDYADFGI YETALLGMLS QASGIATAAL 

       130        140        150        160        170        180 
RIKIAAKFKP VYSFGIRHMH PAIAPMIDRA AFIGGCDGVS GVLGAEMMGE KAVGTMPHAL 

       190        200        210        220        230        240 
IITVGDQVKA WKYFDEVIEE EVPRIALVDT FYDEKVEAVM AAEALGKKLF AVRLDTPSSR 

       250        260        270        280        290        300 
RGNFRKIIEE VRWELKVRGY DWVKIFVSGG LDEEKIKEIV DVVDAFGVGG AIASAKPVDF 

       310        320        330        340        350        360 
ALDIVEVEGK PIAKRGKLSG RKQVYRCENG HYHVVPANKK LERCPVCNAK VEPLLKPIIE 

       370        380 
NGEIVVEFPK AREIREYVLE QAKKFNLEI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Crystal structure of nicotinate-nucleotide pyrophosphorylase from Pyrococcus furiosus." Shin D.H., Kim R., Kim S.-H., Pufan R., Yokota H. Submitted (AUG-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH ZINC.
[2]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE009950 Genomic DNA. Translation: AAL82028.1.

RefSeq

NP_579633.1. NC_003413.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2I14	X-ray	2.90	A/B/C/D/E/F	1-389	[»]

ProteinModelPortal

Q8TZS9.

SMR

Q8TZS9. Positions 1-389.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBPYRT00000004706; EBPYRP00000004567; EBPYRG00000004706.

GeneID

1469784.

GenomeReviews

Gene locus PF1904 in contig AE009950_GR.

KEGG

pfu:PF1904.

NMPDR

fig|186497.1.peg.1954.

Phylogenomic databases

GeneTree

EBGT00050000022888.

HOGENOM

HBG462124.

OMA

HPAIAPM.

PhylomeDB

Q8TZS9.

ProtClustDB

PRK08662.

Family and domain databases

InterPro

IPR013785. Aldolase_TIM.
IPR007229. Nic_PRibTrfase-rel.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]

Gene3D

G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
G3DSA:3.90.1170.20. G3DSA:3.90.1170.20. 1 hit.

KO

K00763.

PANTHER

PTHR11098:SF1. NAPRTase. 1 hit.

Pfam

PF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000484. NAPRT. 1 hit.

SUPFAM

SSF51690. Q_phspho_trans. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q8TZS9_PYRFU

Accession

Primary (citable) accession number: Q8TZS9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)