Q8TZS0 (RNP3_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component 3
Short name=RNase P component 3
EC=3.1.26.5

Gene names

Name:	rnp3
Ordered Locus Names:	PF1914

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity. HAMAP MF_00756
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00756
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tRNA 5'-leader removal Inferred from electronic annotation. Source: InterPro
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Ribonuclease P protein component 3 HAMAP MF_00756		PRO_0000140045

Sequences

	Sequence		Length	Mass (Da)
	Q8TZS0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A915506635C02CFB	FASTA	214	24,495
	10 20 30 40 50 60 MAGGRNGVKF VEMDIRSREA YELAEEWFDD VVFSYEIPPG VLDKERLKEI KKEYGNVAIT 70 80 90 100 110 120 LINPKPSLVK EAVQRFKQNY LIYVESSDLR VVRYSIERGV DAVISPWANR KDQGIDHVLA 130 140 150 160 170 180 RMMNKRGVAL GFSLRPLLHQ NPYERANALK FMRKAWTLVN KYKVPRFISS SAKGKFQVRG 190 200 210 VKELISLGIA IGMEEVQAKA SLSFYPLGIL ERLK

References

[1]

"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009950 Genomic DNA. Translation: AAL82038.1.
RefSeq	NP_579643.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q8TZS0.
SMR	Q8TZS0. Positions 7-214.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TZS0. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000006010; EBPYRP00000005871; EBPYRG00000006009.
GeneID	1469794.
GenomeReviews	Gene locus PF1914 in contig AE009950_GR.
KEGG	pfu:PF1914.
NMPDR	fig|186497.1.peg.1964.
Phylogenomic databases
GeneTree	EBGT00050000022696.
HOGENOM	HBG645643.
OMA	WFDEVVF.
ProtClustDB	PRK03892.
Family and domain databases
HAMAP	MF_00756. RNase_P_3. [Tree]
InterPro	IPR016195. Pol/histidinol_Pase-like. IPR023539. RNase_P_comp-3. IPR002738. RNase_P_p30. [Graphical view]
KO	K03539.
Pfam	PF01876. RNase_P_p30. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RNP3_PYRFU

Accession

Primary (citable) accession number: Q8TZS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program