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Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

PF1963

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.42UniRule annotation)
Short name:
DGGGP synthaseUniRule annotation
Short name:
DGGGPSUniRule annotation
Alternative name(s):
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Geranylgeranylglycerol-phosphate geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:PF1963
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalUniRule annotationAdd
BLAST
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei107 – 12721HelicalUniRule annotationAdd
BLAST
Transmembranei146 – 16621HelicalUniRule annotationAdd
BLAST
Transmembranei200 – 22021HelicalUniRule annotationAdd
BLAST
Transmembranei221 – 24121HelicalUniRule annotationAdd
BLAST
Transmembranei257 – 27721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Digeranylgeranylglyceryl phosphate synthasePRO_0000350716Add
BLAST

Proteomic databases

PRIDEiQ8TZM7.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1963.

Structurei

3D structure databases

ProteinModelPortaliQ8TZM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiKYGMFLA.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TZM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKGFIEIM RPHNCILAGI VGILGALVAY EGIPDIKTLT LIFWVVYFGC
60 70 80 90 100
SGGNTANDYF DYEIDKINRP NRPLPRGAMS RRAALYYALL QYAIGSILAY
110 120 130 140 150
FLNIRAFVFA TIAYFLTFLY GWKLKPLPLV GNITVAALTA ATPIYGAIGV
160 170 180 190 200
GRIGLAGYLA ICAFLVNVSR EIMKDIEDIE GDKALGARTL PIIIGEKKAA
210 220 230 240 250
IIAAIFGFLT VIASFLPVKV GIGLGYAPII IVDIIIIKAS IDVLRDPKAA
260 270
SKGQKLLKIA TFVAVISFLA GALTKGV
Length:277
Mass (Da):29,792
Last modified:June 1, 2002 - v1
Checksum:i84D4839F706D03EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL82087.1.
RefSeqiWP_011013105.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL82087; AAL82087; PF1963.
GeneIDi1469845.
KEGGipfu:PF1963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL82087.1.
RefSeqiWP_011013105.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8TZM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1963.

Proteomic databases

PRIDEiQ8TZM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL82087; AAL82087; PF1963.
GeneIDi1469845.
KEGGipfu:PF1963.

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiKYGMFLA.

Enzyme and pathway databases

UniPathwayiUPA00940.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGGGP_PYRFU
AccessioniPrimary (citable) accession number: Q8TZM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.