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Q8TZL5 (CAPPA_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase

Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppcA
Ordered Locus Names:PF1975
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_01904

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_01904

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01904

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01904

Sequence similarities

Belongs to the PEPCase type 2 family.

Ontologies

Keywords
   Biological processCarbon dioxide fixation
   LigandMagnesium
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbon fixation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

oxaloacetate metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoenolpyruvate carboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Phosphoenolpyruvate carboxylase HAMAP-Rule MF_01904
PRO_0000309612

Sequences

Sequence LengthMass (Da)Tools
Q8TZL5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 430BB52B442C6897

FASTA47254,315
        10         20         30         40         50         60 
MIPRIMSTQH PDNYSIPFFA SSPILEGEDE ITEAFYAFSV LGADEQMWDF EGKEVDEFVV 

        70         80         90        100        110        120 
KKLLERYPTF FKNNILGKDI RLTPRVPNPS VEKEEAKLLL ETLQGIARSA DYARIFYGDN 

       130        140        150        160        170        180 
IAPIFEVILP MTTSVEEIER VYWLYKKAVV WISREKIYDI TVREWIGDFF PEKINVIPLF 

       190        200        210        220        230        240 
ETKSALIKAA KITEAYILNR KNDIEYQRVF FARSDPAMNY GLITAVTYVK RALYEVLKVE 

       250        260        270        280        290        300 
EELSIPIYPI IGVGGPPLRG GMRPDNVDAV VKEYPSVQTF TIQSSFKYDY PTKDVVKAVE 

       310        320        330        340        350        360 
KIKSTKRKLP IPVEIPPFLV NYEAEYQKQI RILAPYINSV AKRIPRRRKR KLHIGLFGYS 

       370        380        390        400        410        420 
RNVNGITLPR AITFTAALYS IGIPPELLAL NSLTDSQLET ISEYYINVYE DLEFAMRFFS 

       430        440        450        460        470 
PKVAEKVGLK ELAERVKEFK PEQIPEYIEE AEIVFKGEGD VMKLAQLRGF LG 

« Hide

References

[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009950 Genomic DNA. Translation: AAL82099.1.
RefSeqNP_579704.1. NC_003413.1.

3D structure databases

ProteinModelPortalQ8TZL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING186497.PF1975.

Proteomic databases

PRIDEQ8TZL5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL82099; AAL82099; PF1975.
GeneID1469857.
KEGGpfu:PF1975.

Phylogenomic databases

eggNOGCOG1892.
HOGENOMHOG000038601.
KOK01595.
OMADEYMPDY.

Family and domain databases

HAMAPMF_01904. PEPcase_type2.
InterProIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFPIRSF006677. UCP006677. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR02751. PEPCase_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCAPPA_PYRFU
AccessionPrimary (citable) accession number: Q8TZL5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families