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Q8TZL5

- CAPPA_PYRFU

UniProt

Q8TZL5 - CAPPA_PYRFU

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium.UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:PF1975
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Phosphoenolpyruvate carboxylasePRO_0000309612Add
BLAST

Proteomic databases

PRIDEiQ8TZL5.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF1975.

Structurei

3D structure databases

ProteinModelPortaliQ8TZL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000038601.
KOiK01595.
OMAiDEYMPDY.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TZL5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPRIMSTQH PDNYSIPFFA SSPILEGEDE ITEAFYAFSV LGADEQMWDF
60 70 80 90 100
EGKEVDEFVV KKLLERYPTF FKNNILGKDI RLTPRVPNPS VEKEEAKLLL
110 120 130 140 150
ETLQGIARSA DYARIFYGDN IAPIFEVILP MTTSVEEIER VYWLYKKAVV
160 170 180 190 200
WISREKIYDI TVREWIGDFF PEKINVIPLF ETKSALIKAA KITEAYILNR
210 220 230 240 250
KNDIEYQRVF FARSDPAMNY GLITAVTYVK RALYEVLKVE EELSIPIYPI
260 270 280 290 300
IGVGGPPLRG GMRPDNVDAV VKEYPSVQTF TIQSSFKYDY PTKDVVKAVE
310 320 330 340 350
KIKSTKRKLP IPVEIPPFLV NYEAEYQKQI RILAPYINSV AKRIPRRRKR
360 370 380 390 400
KLHIGLFGYS RNVNGITLPR AITFTAALYS IGIPPELLAL NSLTDSQLET
410 420 430 440 450
ISEYYINVYE DLEFAMRFFS PKVAEKVGLK ELAERVKEFK PEQIPEYIEE
460 470
AEIVFKGEGD VMKLAQLRGF LG
Length:472
Mass (Da):54,315
Last modified:June 1, 2002 - v1
Checksum:i430BB52B442C6897
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL82099.1.
RefSeqiNP_579704.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL82099; AAL82099; PF1975.
GeneIDi1469857.
KEGGipfu:PF1975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL82099.1 .
RefSeqi NP_579704.1. NC_003413.1.

3D structure databases

ProteinModelPortali Q8TZL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF1975.

Proteomic databases

PRIDEi Q8TZL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL82099 ; AAL82099 ; PF1975 .
GeneIDi 1469857.
KEGGi pfu:PF1975.

Phylogenomic databases

eggNOGi COG1892.
HOGENOMi HOG000038601.
KOi K01595.
OMAi DEYMPDY.

Family and domain databases

HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiCAPPA_PYRFU
AccessioniPrimary (citable) accession number: Q8TZL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3