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Q8TZJ3 (GCSPA_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:PF1999
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166985

Sequences

Sequence LengthMass (Da)Tools
Q8TZJ3 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 6C56E99A68754E9E

FASTA44850,200
        10         20         30         40         50         60 
MGKHYIPNSA HKEEMLKEIG FSSIEELFAD VPEGFIREFN VPEGKSEYEV FMEMNEILSK 

        70         80         90        100        110        120 
NKTVLEMPTF LGAGTYFHYV PAHVKYLIER SEFLTSYTPY QAEISQGMLQ ALFEYQSLIA 

       130        140        150        160        170        180 
ELVGLPVVNS SMYDWGSALG EAALMTVRLH RGKRLKFVVP KHTHPERMQV LKTYTRGANL 

       190        200        210        220        230        240 
EIVEVKWNDR GQVDLEDLKE KVNDAAGVYV EIPNFFGLLE ENIQEIGEIA HEAGAYFVVG 

       250        260        270        280        290        300 
VDPTILGVVE APGELGADIV VGEASYFGSP MNFGGPRAGI FATRNDPKFI RQMPGRIIGM 

       310        320        330        340        350        360 
TKDAEGKRAF VMTLQTREQH IRRAKATSNI CSNEALVAVA AAIHIASLGP KGMQELGEVI 

       370        380        390        400        410        420 
LKNTAYLKKR LSEVAEIPFD GVNFKDVLVK FEKPYQEIHE HLLQKNIHGG YYVKPHFPEL 

       430        440 
GESALFAATE TTRKEWIDAL IDALREVL 

« Hide

References

[1]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009950 Genomic DNA. Translation: AAL82123.1.
RefSeqNP_579728.1. NC_003413.1.

3D structure databases

ProteinModelPortalQ8TZJ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING186497.PF1999.

Proteomic databases

PRIDEQ8TZJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL82123; AAL82123; PF1999.
GeneID1469883.
KEGGpfu:PF1999.

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
ProtClustDBPRK00451.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_PYRFU
AccessionPrimary (citable) accession number: Q8TZJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families