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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:PF1999
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669851 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PRIDEiQ8TZJ3

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF1999

Structurei

3D structure databases

ProteinModelPortaliQ8TZJ3
SMRiQ8TZJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00077 Archaea
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TZJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKHYIPNSA HKEEMLKEIG FSSIEELFAD VPEGFIREFN VPEGKSEYEV
60 70 80 90 100
FMEMNEILSK NKTVLEMPTF LGAGTYFHYV PAHVKYLIER SEFLTSYTPY
110 120 130 140 150
QAEISQGMLQ ALFEYQSLIA ELVGLPVVNS SMYDWGSALG EAALMTVRLH
160 170 180 190 200
RGKRLKFVVP KHTHPERMQV LKTYTRGANL EIVEVKWNDR GQVDLEDLKE
210 220 230 240 250
KVNDAAGVYV EIPNFFGLLE ENIQEIGEIA HEAGAYFVVG VDPTILGVVE
260 270 280 290 300
APGELGADIV VGEASYFGSP MNFGGPRAGI FATRNDPKFI RQMPGRIIGM
310 320 330 340 350
TKDAEGKRAF VMTLQTREQH IRRAKATSNI CSNEALVAVA AAIHIASLGP
360 370 380 390 400
KGMQELGEVI LKNTAYLKKR LSEVAEIPFD GVNFKDVLVK FEKPYQEIHE
410 420 430 440
HLLQKNIHGG YYVKPHFPEL GESALFAATE TTRKEWIDAL IDALREVL
Length:448
Mass (Da):50,200
Last modified:June 1, 2002 - v1
Checksum:i6C56E99A68754E9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL82123.1
RefSeqiWP_011013143.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL82123; AAL82123; PF1999
GeneIDi1469883
KEGGipfu:PF1999
PATRICifig|186497.12.peg.2075

Similar proteinsi

Entry informationi

Entry nameiGCSPA_PYRFU
AccessioniPrimary (citable) accession number: Q8TZJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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