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Q8TZJ2

- GCSPB_PYRFU

UniProt

Q8TZJ2 - GCSPB_PYRFU

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, PF2000
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:PF2000
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_0000167028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ8TZJ2.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi186497.PF2000.

Structurei

3D structure databases

ProteinModelPortaliQ8TZJ2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiLGETPWD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TZJ2-1 [UniParc]FASTAAdd to Basket

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MFRQAKWDEP LIFELSRPGR VGYTLPKPIE DIKVDIPEKL RRKSKLELPE    50
LSEPEIVKHY TRLSEMNYGV DSGIYPLGSC TMKYNPKINE EIATHPKVAY 100
IHPYQDERTV QGALAIMWEL EQWLKEITGM DRFTLQPAAG ANGEFTGVMI 150
IRAYHLDNGE PQRNEMLVPD SAHGTNPASA AMAGFKVIEI PSNENGTIDL 200
EALENAVSER TAGLMLTNPN TLGIFEDEIV EIAKIIHKAG GLLYYDGANL 250
NGILGKIRPG DMGFDIVHLN LHKTFSTPHG GGGPGAGPVG VKEFLKDYLP 300
VPLVSYDEKS GRYYLDYNVP KSIGKVKELY GNFAVLVRAL TYLKIMGRDG 350
LREVSEIAVL NANYLTQKLK GTRGYSLPGK ELRKHEVVFS AEPMKKETGV 400
KALDVAKRLL DFGMHAPTIY FPLIVHEALM IEPTETVSKE ELDAYVEALK 450
RISEEAYTNP EIVKSAPHNT AVKRVDDVLA AKKPIVTWRM YKELKEKGEV 500
DY 502
Length:502
Mass (Da):56,113
Last modified:June 1, 2002 - v1
Checksum:i70BE4DC35055A565
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL82124.1.
RefSeqiNP_579729.1. NC_003413.1.
WP_011013144.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL82124; AAL82124; PF2000.
GeneIDi1469884.
KEGGipfu:PF2000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009950 Genomic DNA. Translation: AAL82124.1 .
RefSeqi NP_579729.1. NC_003413.1.
WP_011013144.1. NC_003413.1.

3D structure databases

ProteinModelPortali Q8TZJ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF2000.

Proteomic databases

PRIDEi Q8TZJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL82124 ; AAL82124 ; PF2000 .
GeneIDi 1469884.
KEGGi pfu:PF2000.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi LGETPWD.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiGCSPB_PYRFU
AccessioniPrimary (citable) accession number: Q8TZJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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