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Protein
Submitted name:

ATP-dependent RNA helicase, putative

Gene

PF2015

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi584 – 5841CalciumCombined sources
Metal bindingi594 – 5941CalciumCombined sources
Metal bindingi595 – 5951Calcium; via carbonyl oxygenCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseImported, Hydrolase

Keywords - Ligandi

ATP-binding, CalciumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-dependent RNA helicase, putativeImported
Gene namesi
Ordered Locus Names:PF2015Imported
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)Imported
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ8TZH8.

Interactioni

Protein-protein interaction databases

DIPiDIP-48431N.
STRINGi186497.PF2015.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J22X-ray1.80A548-689[»]
1J23X-ray1.78A548-689[»]
1J24X-ray1.78A548-689[»]
1J25X-ray1.78A548-689[»]
1WP9X-ray2.90A/B/C/D/E/F2-495[»]
1X2IX-ray1.45A/B691-764[»]
ProteinModelPortaliQ8TZH8.
SMRiQ8TZH8. Positions 2-487, 550-682, 694-761.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TZH8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 185168Helicase ATP-bindingInterPro annotationAdd
BLAST
Domaini345 – 512168Helicase C-terminalInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiarCOG00872. Archaea.
COG1111. LUCA.
COG1948. LUCA.
HOGENOMiHOG000223976.
KOiK10896.
OMAiTNYRETA.

Family and domain databases

Gene3Di3.40.50.10130. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR011335. Restrct_endonuc-II-like.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF02732. ERCC4. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00891. ERCC4. 1 hit.
SM00490. HELICc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF52980. SSF52980. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TZH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLLRRDLIQ PRIYQEVIYA KCKETNCLIV LPTGLGKTLI AMMIAEYRLT
60 70 80 90 100
KYGGKVLMLA PTKPLVLQHA ESFRRLFNLP PEKIVALTGE KSPEERSKAW
110 120 130 140 150
ARAKVIVATP QTIENDLLAG RISLEDVSLI VFDEAHRAVG NYAYVFIARE
160 170 180 190 200
YKRQAKNPLV IGLTASPGST PEKIMEVINN LGIEHIEYRS ENSPDVRPYV
210 220 230 240 250
KGIRFEWVRV DLPEIYKEVR KLLREMLRDA LKPLAETGLL ESSSPDIPKK
260 270 280 290 300
EVLRAGQIIN EEMAKGNHDL RGLLLYHAMA LKLHHAIELL ETQGLSALRA
310 320 330 340 350
YIKKLYEEAK AGSTKASKEI FSDKRMKKAI SLLVQAKEIG LDHPKMDKLK
360 370 380 390 400
EIIREQLQRK QNSKIIVFTN YRETAKKIVN ELVKDGIKAK RFVGQASKEN
410 420 430 440 450
DRGLSQREQK LILDEFARGE FNVLVATSVG EEGLDVPEVD LVVFYEPVPS
460 470 480 490 500
AIRSIQRRGR TGRHMPGRVI ILMAKGTRDE AYYWSSRQKE KIMQETIAKV
510 520 530 540 550
SQAIKKQKQT SLVDFVREKE SEKTSLDKWL KKEKEEATEK EEKKVKAQEG
560 570 580 590 600
VKVVVDSREL RSEVVKRLKL LGVKLEVKTL DVGDYIISED VAIERKSAND
610 620 630 640 650
FIQSIIDGRL FDQVKRLKEA YSRPIMIVEG SLYGIRNVHP NAIRGAIAAV
660 670 680 690 700
TVDFGVPIIF SSTPEETAQY IFLIAKREQE EREKPVRIRS EKKALTLAER
710 720 730 740 750
QRLIVEGLPH VSATLARRLL KHFGSVERVF TASVAELMKV EGIGEKIAKE
760
IRRVITAPYI EDEE
Length:764
Mass (Da):86,939
Last modified:June 1, 2002 - v1
Checksum:i0561F58EB8E15679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL82139.1.

Genome annotation databases

EnsemblBacteriaiAAL82139; AAL82139; PF2015.
KEGGipfu:PF2015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL82139.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J22X-ray1.80A548-689[»]
1J23X-ray1.78A548-689[»]
1J24X-ray1.78A548-689[»]
1J25X-ray1.78A548-689[»]
1WP9X-ray2.90A/B/C/D/E/F2-495[»]
1X2IX-ray1.45A/B691-764[»]
ProteinModelPortaliQ8TZH8.
SMRiQ8TZH8. Positions 2-487, 550-682, 694-761.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48431N.
STRINGi186497.PF2015.

Proteomic databases

PRIDEiQ8TZH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL82139; AAL82139; PF2015.
KEGGipfu:PF2015.

Phylogenomic databases

eggNOGiarCOG00872. Archaea.
COG1111. LUCA.
COG1948. LUCA.
HOGENOMiHOG000223976.
KOiK10896.
OMAiTNYRETA.

Miscellaneous databases

EvolutionaryTraceiQ8TZH8.

Family and domain databases

Gene3Di3.40.50.10130. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR011335. Restrct_endonuc-II-like.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF02732. ERCC4. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00891. ERCC4. 1 hit.
SM00490. HELICc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF52980. SSF52980. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8TZH8_PYRFU
AccessioniPrimary (citable) accession number: Q8TZH8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.