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Protein

tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2

Gene

taw3-2

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2UniRule annotation (EC:2.1.1.282UniRule annotation)
Alternative name(s):
tRNA wyosine derivatives biosynthesis protein Taw3 2UniRule annotation
Gene namesi
Name:taw3-2UniRule annotation
Ordered Locus Names:PF2034
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2PRO_0000157099Add
BLAST

Proteomic databases

PRIDEiQ8TZG0.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF2034.

Structurei

3D structure databases

ProteinModelPortaliQ8TZG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TYW3 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04156. Archaea.
COG1590. LUCA.
HOGENOMiHOG000222308.
OMAiGFKYTTF.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
HAMAPiMF_00266. TYW3_archaea. 1 hit.
InterProiIPR022908. Taw3.
IPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TZG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKREALLS LFQAIKENKV DEDIVELLLL INSIKGVYTT SSCSGRIGII
60 70 80 90 100
EEPSLGAKPL SRWLIKVHRP IKFEEAKKAL KNAQKGLIFL KSQPPIFHVV
110 120 130 140 150
TESLELARKI HEIGLSSGFK YTTYKVISRR YLVEINGTEY LTVPLGKDGK
160 170 180 190 200
VFVTDEYLEF VIEIGNQMLM RGKSRLPRLR EKFEELKEEV GEDPLFTTLS

TEKLSL
Length:206
Mass (Da):23,469
Last modified:October 10, 2002 - v2
Checksum:i33B0FBF85FE4D502
GO

Sequence cautioni

The sequence AAL82158 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL82158.1. Different initiation.
RefSeqiWP_014835510.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL82158; AAL82158; PF2034.
GeneIDi1469919.
KEGGipfu:PF2034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL82158.1. Different initiation.
RefSeqiWP_014835510.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8TZG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF2034.

Proteomic databases

PRIDEiQ8TZG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL82158; AAL82158; PF2034.
GeneIDi1469919.
KEGGipfu:PF2034.

Phylogenomic databases

eggNOGiarCOG04156. Archaea.
COG1590. LUCA.
HOGENOMiHOG000222308.
OMAiGFKYTTF.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
HAMAPiMF_00266. TYW3_archaea. 1 hit.
InterProiIPR022908. Taw3.
IPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTYW32_PYRFU
AccessioniPrimary (citable) accession number: Q8TZG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 11, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.