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Protein

tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2

Gene

taw3-2

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2UniRule annotation (EC:2.1.1.282UniRule annotation)
Alternative name(s):
tRNA wyosine derivatives biosynthesis protein Taw3 2UniRule annotation
Gene namesi
Name:taw3-2UniRule annotation
Ordered Locus Names:PF2034
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001570991 – 206tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2Add BLAST206

Proteomic databases

PRIDEiQ8TZG0

Interactioni

Protein-protein interaction databases

STRINGi186497.PF2034

Structurei

3D structure databases

ProteinModelPortaliQ8TZG0
SMRiQ8TZG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TYW3 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04156 Archaea
COG1590 LUCA
HOGENOMiHOG000222308
KOiK15450
OMAiGFKYTTF
OrthoDBiPOG093Z0FD3

Family and domain databases

Gene3Di3.30.1960.10, 1 hit
HAMAPiMF_00266 TYW3_archaea, 1 hit
InterProiView protein in InterPro
IPR022908 Taw3
IPR003827 tRNA_yW-synthesising
IPR036602 tRNA_yW-synthesising-like_sf
PfamiView protein in Pfam
PF02676 TYW3, 1 hit
SUPFAMiSSF111278 SSF111278, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TZG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKREALLS LFQAIKENKV DEDIVELLLL INSIKGVYTT SSCSGRIGII
60 70 80 90 100
EEPSLGAKPL SRWLIKVHRP IKFEEAKKAL KNAQKGLIFL KSQPPIFHVV
110 120 130 140 150
TESLELARKI HEIGLSSGFK YTTYKVISRR YLVEINGTEY LTVPLGKDGK
160 170 180 190 200
VFVTDEYLEF VIEIGNQMLM RGKSRLPRLR EKFEELKEEV GEDPLFTTLS

TEKLSL
Length:206
Mass (Da):23,469
Last modified:October 10, 2002 - v2
Checksum:i33B0FBF85FE4D502
GO

Sequence cautioni

The sequence AAL82158 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL82158.1 Different initiation.
RefSeqiWP_014835510.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL82158; AAL82158; PF2034
GeneIDi1469919
KEGGipfu:PF2034
PATRICifig|186497.12.peg.2111

Similar proteinsi

Entry informationi

Entry nameiTYW32_PYRFU
AccessioniPrimary (citable) accession number: Q8TZG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: March 28, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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