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Q8TZC4

- RFCS_METKA

UniProt

Q8TZC4 - RFCS_METKA

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Protein

Replication factor C small subunit

Gene
rfcS, MK0006
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. four-way junction helicase activity Source: InterPro

GO - Biological processi

  1. DNA recombination Source: InterPro
  2. DNA repair Source: InterPro
  3. DNA replication Source: UniProtKB-KW
  4. intein-mediated protein splicing Source: InterPro
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C small subunit
Short name:
RFC small subunit
Alternative name(s):
Clamp loader small subunit
Cleaved into the following chain:
Gene namesi
Name:rfcS
Ordered Locus Names:MK0006
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8282Replication factor C small subunit, 1st part Reviewed predictionPRO_0000030368Add
BLAST
Chaini83 – 387305Mkn RFC intein Reviewed predictionPRO_0000030369Add
BLAST
Chaini388 – 635248Replication factor C small subunit, 2nd part Reviewed predictionPRO_0000030370Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Reviewed prediction.

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Subunit structurei

Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL) By similarity.

Protein-protein interaction databases

STRINGi190192.MK0006.

Structurei

3D structure databases

ProteinModelPortaliQ8TZC4.
SMRiQ8TZC4. Positions 5-83, 385-629.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000154101.
KOiK04801.
OMAiNWRYEFR.

Family and domain databases

Gene3Di2.170.16.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006142. INTEIN.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR013748. Rep_factorC_C_dom.
[Graphical view]
PfamiPF08542. Rep_fac_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
PRINTSiPR00379. INTEIN.
SMARTiSM00382. AAA. 1 hit.
SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TZC4-1 [UniParc]FASTAAdd to Basket

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MAEHELRVLE IPWVEKYRPK RLDDIVDQEH VVERLKAYVN RGDMPNLLFA    50
GPPGTGKTTA ALCLARELFG EHWRDNFLEL NASVSADTPI LVRRGGEVLR 100
VTFEDLDSWY FGDRGGEYVD VSDLEVLTVD RNFRVTWARV SKLIRHRARK 150
ILRVHLEDGT IELTGNHAVM VLDEGGLRAV KASEIEEGSF LLSFVAELDE 200
QPTDGGTVVT SVGSGSRVSD TTYELPVEVR VELLRELADD GVIEASEDVS 250
VDLAWLARIS GVESRVTDDG VELVWETRTG DLLPADPVLK LVERLESDLV 300
DDLESWVFDG RVSKEAVRKV LSSVDAKNLR GDARRAYRML RTLVRSDVHA 350
VKVEDLDVMD YDGYVYDVSV PGNEMFFAGE VPVLLHNSDE RGIDVIRTKV 400
KNFARTRPMG GARFKIIFLD EADNLTRDSQ QALRRIMEMY SDACRFILAA 450
NYSSAIIDPI QSRCVVFKFT KLPESAIKER LRKIAESEGV EITEDALDAI 500
VYVSEGDMRR AINVLQAAAA LGREIDEDTV FQIAATARPE EVREMIHHAW 550
NGDFERAREL LHELLTRYGM SGEDVVRQVH REIFDMDEIP EEAIPELVNA 600
VGDFEYRLIR GSDERIQLEA LLARIHALGN EYSGG 635
Length:635
Mass (Da):71,586
Last modified:June 1, 2002 - v1
Checksum:i9AC69359719E08C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM01223.1.
RefSeqiNP_613293.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM01223; AAM01223; MK0006.
GeneIDi1477308.
KEGGimka:MK0006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM01223.1 .
RefSeqi NP_613293.1. NC_003551.1.

3D structure databases

ProteinModelPortali Q8TZC4.
SMRi Q8TZC4. Positions 5-83, 385-629.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190192.MK0006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM01223 ; AAM01223 ; MK0006 .
GeneIDi 1477308.
KEGGi mka:MK0006.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000154101.
KOi K04801.
OMAi NWRYEFR.

Family and domain databases

Gene3Di 2.170.16.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006142. INTEIN.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR013748. Rep_factorC_C_dom.
[Graphical view ]
Pfami PF08542. Rep_fac_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view ]
PRINTSi PR00379. INTEIN.
SMARTi SM00382. AAA. 1 hit.
SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view ]
SUPFAMi SSF48019. SSF48019. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEi PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Entry informationi

Entry nameiRFCS_METKA
AccessioniPrimary (citable) accession number: Q8TZC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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