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Q8TZC4

- RFCS_METKA

UniProt

Q8TZC4 - RFCS_METKA

Protein

Replication factor C small subunit

Gene

rfcS

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi51 – 588ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. four-way junction helicase activity Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: InterPro
    2. DNA repair Source: InterPro
    3. DNA replication Source: UniProtKB-KW
    4. intein-mediated protein splicing Source: InterPro

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Replication factor C small subunit
    Short name:
    RFC small subunit
    Alternative name(s):
    Clamp loader small subunit
    Cleaved into the following chain:
    Gene namesi
    Name:rfcS
    Ordered Locus Names:MK0006
    OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
    Taxonomic identifieri190192 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
    ProteomesiUP000001826: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8282Replication factor C small subunit, 1st partSequence AnalysisPRO_0000030368Add
    BLAST
    Chaini83 – 387305Mkn RFC inteinSequence AnalysisPRO_0000030369Add
    BLAST
    Chaini388 – 635248Replication factor C small subunit, 2nd partSequence AnalysisPRO_0000030370Add
    BLAST

    Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

    Keywords - PTMi

    Autocatalytic cleavage, Protein splicing

    Interactioni

    Subunit structurei

    Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).By similarity

    Protein-protein interaction databases

    STRINGi190192.MK0006.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TZC4.
    SMRiQ8TZC4. Positions 5-83, 385-629.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000154101.
    KOiK04801.
    OMAiNWRYEFR.

    Family and domain databases

    Gene3Di2.170.16.10. 2 hits.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR008824. DNA_helicase_Holl-junc_RuvB_N.
    IPR008921. DNA_pol3_clamp-load_cplx_C.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR006142. INTEIN.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR013748. Rep_factorC_C_dom.
    [Graphical view]
    PfamiPF08542. Rep_fac_C. 1 hit.
    PF05496. RuvB_N. 1 hit.
    [Graphical view]
    PRINTSiPR00379. INTEIN.
    SMARTiSM00382. AAA. 1 hit.
    SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48019. SSF48019. 1 hit.
    SSF51294. SSF51294. 2 hits.
    SSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEiPS50818. INTEIN_C_TER. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8TZC4-1 [UniParc]FASTAAdd to Basket

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    MAEHELRVLE IPWVEKYRPK RLDDIVDQEH VVERLKAYVN RGDMPNLLFA    50
    GPPGTGKTTA ALCLARELFG EHWRDNFLEL NASVSADTPI LVRRGGEVLR 100
    VTFEDLDSWY FGDRGGEYVD VSDLEVLTVD RNFRVTWARV SKLIRHRARK 150
    ILRVHLEDGT IELTGNHAVM VLDEGGLRAV KASEIEEGSF LLSFVAELDE 200
    QPTDGGTVVT SVGSGSRVSD TTYELPVEVR VELLRELADD GVIEASEDVS 250
    VDLAWLARIS GVESRVTDDG VELVWETRTG DLLPADPVLK LVERLESDLV 300
    DDLESWVFDG RVSKEAVRKV LSSVDAKNLR GDARRAYRML RTLVRSDVHA 350
    VKVEDLDVMD YDGYVYDVSV PGNEMFFAGE VPVLLHNSDE RGIDVIRTKV 400
    KNFARTRPMG GARFKIIFLD EADNLTRDSQ QALRRIMEMY SDACRFILAA 450
    NYSSAIIDPI QSRCVVFKFT KLPESAIKER LRKIAESEGV EITEDALDAI 500
    VYVSEGDMRR AINVLQAAAA LGREIDEDTV FQIAATARPE EVREMIHHAW 550
    NGDFERAREL LHELLTRYGM SGEDVVRQVH REIFDMDEIP EEAIPELVNA 600
    VGDFEYRLIR GSDERIQLEA LLARIHALGN EYSGG 635
    Length:635
    Mass (Da):71,586
    Last modified:June 1, 2002 - v1
    Checksum:i9AC69359719E08C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009439 Genomic DNA. Translation: AAM01223.1.
    RefSeqiNP_613293.1. NC_003551.1.

    Genome annotation databases

    EnsemblBacteriaiAAM01223; AAM01223; MK0006.
    GeneIDi1477308.
    KEGGimka:MK0006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009439 Genomic DNA. Translation: AAM01223.1 .
    RefSeqi NP_613293.1. NC_003551.1.

    3D structure databases

    ProteinModelPortali Q8TZC4.
    SMRi Q8TZC4. Positions 5-83, 385-629.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190192.MK0006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM01223 ; AAM01223 ; MK0006 .
    GeneIDi 1477308.
    KEGGi mka:MK0006.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000154101.
    KOi K04801.
    OMAi NWRYEFR.

    Family and domain databases

    Gene3Di 2.170.16.10. 2 hits.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR008824. DNA_helicase_Holl-junc_RuvB_N.
    IPR008921. DNA_pol3_clamp-load_cplx_C.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR006142. INTEIN.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR013748. Rep_factorC_C_dom.
    [Graphical view ]
    Pfami PF08542. Rep_fac_C. 1 hit.
    PF05496. RuvB_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00379. INTEIN.
    SMARTi SM00382. AAA. 1 hit.
    SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48019. SSF48019. 1 hit.
    SSF51294. SSF51294. 2 hits.
    SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEi PS50818. INTEIN_C_TER. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

    Entry informationi

    Entry nameiRFCS_METKA
    AccessioniPrimary (citable) accession number: Q8TZC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3