Reviewed, UniProtKB/Swiss-Prot Q8TZB0 (KADA_METKA)

Names and origin

Protein names

Recommended name:
    Adenylate kinase
      Short name=AK
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase

Gene names

Name:	adkA
Ordered Locus Names:	MK0025

Organism

Methanopyrus kandleri [Complete proteome] [HAMAP]

Taxonomic identifier

2320 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00234
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the archaeal adenylate kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Adenylate kinase HAMAP MF_00234		PRO_0000131815
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TZB0-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 3A34413D4073D1EA	FASTA	191	21,692
	10 20 30 40 50 60 MGYVIVATGV PGVGATTVTT EAVKELEGYE HVNYGDVMLE IAKEEGLVEH RDEIRKLPAE 70 80 90 100 110 120 KQREIQRLAA RRIAKMAEEK EGIIVDTHCT IKTPAGYLPG LPIWVLEELQ PDVIVLIEAD 130 140 150 160 170 180 PDEIMMRRVK DSEERQRDYD RAHEIEEHQK MNRMAAMAYA ALTGATVKII ENHDDRLEEA 190 VREFVETVRS L

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010303 Genomic DNA. Translation: AAM01242.1.
RefSeq	NP_613312.1.
3D structure databases
HSSP	HSSP built from PDB template 1KHT based on UniProtKB P43411.
ModBase	Search...
Genome annotation databases
GeneID	1477328.
GenomeReviews	Gene locus MK0025 in contig AE009439_GR.
KEGG	mka:MK0025.
NMPDR	fig|190192.1.peg.25.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8TZB0.
OMA	Q8TZB0. HRDEMRK.
Enzyme and pathway databases
BioCyc	MKAN190192:MK0025-MON.
BRENDA	2.7.4.3. 7577.
Family and domain databases
HAMAP	MF_00234. [Tree]
ProtoNet	Search...

Entry information

Entry name

KADA_METKA

Accession

Primary (citable) accession number: Q8TZB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)