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Protein

IMP cyclohydrolase

Gene

purO

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:MK0087
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457961 – 198IMP cyclohydrolaseAdd BLAST198

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0087

Structurei

3D structure databases

ProteinModelPortaliQ8TZ52
SMRiQ8TZ52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727 Archaea
COG3363 LUCA
HOGENOMiHOG000015497
KOiK11176
OMAiSHVDPIA
OrthoDBiPOG093Z0CY5

Family and domain databases

Gene3Di3.60.20.20, 1 hit
HAMAPiMF_00705 IMP_cyclohydrol, 1 hit
InterProiView protein in InterPro
IPR010191 IMP_cyclohydrolase
IPR020600 IMP_cyclohydrolase-like
IPR036795 IMP_cyclohydrolase-like_sf
PfamiView protein in Pfam
PF07826 IMP_cyclohyd, 1 hit
PIRSFiPIRSF004866 IMP_cclhdr_arch, 1 hit
SUPFAMiSSF75569 SSF75569, 1 hit
TIGRFAMsiTIGR01922 purO_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TZ52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVGRFLLAG KLEDGTPIAV YGVCSRSFSD RRIEVREGAA FVVPEDPSYI
60 70 80 90 100
TENPYVTYTC ARIVDEFLVL TNGAQTDPIA DKLESGVPPR EALVSVTFAM
110 120 130 140 150
DYEHDEYNTP RISLITDGET FWLGRVAPEE VYFRVMKPKD GEGYLLSVYG
160 170 180 190
EYAEVPSKPN MTLDREDPLE CDPVPSFEHY VCSVIARHDG GRWSLEAR
Length:198
Mass (Da):22,289
Last modified:June 1, 2002 - v1
Checksum:i8876A09F18FB18C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01304.1

Genome annotation databases

EnsemblBacteriaiAAM01304; AAM01304; MK0087
KEGGimka:MK0087

Entry informationi

Entry nameiPURO_METKA
AccessioniPrimary (citable) accession number: Q8TZ52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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