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Protein

IMP cyclohydrolase

Gene

purO

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:MK0087
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457961 – 198IMP cyclohydrolaseAdd BLAST198

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0087.

Structurei

3D structure databases

ProteinModelPortaliQ8TZ52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727. Archaea.
COG3363. LUCA.
HOGENOMiHOG000015497.
KOiK11176.
OMAiYIGRFLV.

Family and domain databases

Gene3Di3.60.20.20. 1 hit.
HAMAPiMF_00705. IMP_cyclohydrol. 1 hit.
InterProiIPR010191. IMP_cyclohydrolase.
IPR020600. IMP_cyclohydrolase-like.
[Graphical view]
PfamiPF07826. IMP_cyclohyd. 1 hit.
[Graphical view]
PIRSFiPIRSF004866. IMP_cclhdr_arch. 1 hit.
SUPFAMiSSF75569. SSF75569. 1 hit.
TIGRFAMsiTIGR01922. purO_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TZ52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVGRFLLAG KLEDGTPIAV YGVCSRSFSD RRIEVREGAA FVVPEDPSYI
60 70 80 90 100
TENPYVTYTC ARIVDEFLVL TNGAQTDPIA DKLESGVPPR EALVSVTFAM
110 120 130 140 150
DYEHDEYNTP RISLITDGET FWLGRVAPEE VYFRVMKPKD GEGYLLSVYG
160 170 180 190
EYAEVPSKPN MTLDREDPLE CDPVPSFEHY VCSVIARHDG GRWSLEAR
Length:198
Mass (Da):22,289
Last modified:June 1, 2002 - v1
Checksum:i8876A09F18FB18C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM01304.1.

Genome annotation databases

EnsemblBacteriaiAAM01304; AAM01304; MK0087.
KEGGimka:MK0087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM01304.1.

3D structure databases

ProteinModelPortaliQ8TZ52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK0087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM01304; AAM01304; MK0087.
KEGGimka:MK0087.

Phylogenomic databases

eggNOGiarCOG04727. Archaea.
COG3363. LUCA.
HOGENOMiHOG000015497.
KOiK11176.
OMAiYIGRFLV.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135.

Family and domain databases

Gene3Di3.60.20.20. 1 hit.
HAMAPiMF_00705. IMP_cyclohydrol. 1 hit.
InterProiIPR010191. IMP_cyclohydrolase.
IPR020600. IMP_cyclohydrolase-like.
[Graphical view]
PfamiPF07826. IMP_cyclohyd. 1 hit.
[Graphical view]
PIRSFiPIRSF004866. IMP_cclhdr_arch. 1 hit.
SUPFAMiSSF75569. SSF75569. 1 hit.
TIGRFAMsiTIGR01922. purO_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPURO_METKA
AccessioniPrimary (citable) accession number: Q8TZ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.