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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128NAD; via amide nitrogenUniRule annotation1
Binding sitei183NADUniRule annotation1
Active sitei213UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:MK0094
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448971 – 262Probable L-aspartate dehydrogenaseAdd BLAST262

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0094

Structurei

3D structure databases

ProteinModelPortaliQ8TZ45
SMRiQ8TZ45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00254 Archaea
COG1712 LUCA
HOGENOMiHOG000206326
KOiK06989
OMAiINRIEST
OrthoDBiPOG093Z0FE7

Family and domain databases

HAMAPiMF_01265 NadX, 1 hit
InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR002811 Asp_DH
IPR022487 Asp_DH_arc
IPR020626 Asp_DH_prok
IPR011182 L-Asp_DH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01958 DUF108, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF005227 Asp_dh_NAD_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03855 NAD_NadX, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TZ45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLSLALVG AGGIGTTVLR EIREGRLEGK VEPVLVCDRH PEKLKRIERW
60 70 80 90 100
FPDCDTSTDL DDAMSAEADV LLEAASVEAA ASLLPDALKR FDVIVMSVGA
110 120 130 140 150
LVLEEGLLSR CREVAEVTGH RLHVPSGAVG GLDVLRALRG RVREVTLTTI
160 170 180 190 200
KPPKALNKDV SERTVLYEGS VRDAVRKFPK NINVAAAVSL AVGDPSLVTV
210 220 230 240 250
RIVCDPEVSV NTHVIEVESS AGTYRFELRN EALPDNPKTS AVAAYSAVAL
260
IERMTEGIRV GT
Length:262
Mass (Da):28,185
Last modified:June 1, 2002 - v1
Checksum:i298438D77FC7BD75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01311.1

Genome annotation databases

EnsemblBacteriaiAAM01311; AAM01311; MK0094
KEGGimka:MK0094

Entry informationi

Entry nameiASPD_METKA
AccessioniPrimary (citable) accession number: Q8TZ45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health