Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Shikimate dehydrogenase (NADP(+))

Gene

aroE

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).UniRule annotation

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. no protein annotated in this organism
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71ShikimateUniRule annotation1
Active sitei75Proton acceptorUniRule annotation1
Binding sitei96ShikimateUniRule annotation1
Binding sitei111ShikimateUniRule annotation1
Binding sitei233NADP; via carbonyl oxygenUniRule annotation1
Binding sitei235ShikimateUniRule annotation1
Binding sitei256NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi136 – 140NADPUniRule annotation5
Nucleotide bindingi160 – 165NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00087

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (NADP(+))UniRule annotation (EC:1.1.1.25UniRule annotation)
Short name:
SDHUniRule annotation
Gene namesi
Name:aroEUniRule annotation
Ordered Locus Names:MK0117
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001360611 – 290Shikimate dehydrogenase (NADP(+))Add BLAST290

Proteomic databases

PRIDEiQ8TZ24

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190192.MK0117

Structurei

3D structure databases

ProteinModelPortaliQ8TZ24
SMRiQ8TZ24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Shikimate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01033 Archaea
COG0169 LUCA
HOGENOMiHOG000237875
KOiK00014
OMAiFGNPIKH
OrthoDBiPOG093Z09ZR

Family and domain databases

HAMAPiMF_00222 Shikimate_DH_AroE, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR011342 Shikimate_DH
IPR013708 Shikimate_DH-bd_N
IPR022893 Shikimate_DH_fam
IPR006151 Shikm_DH/Glu-tRNA_Rdtase
PfamiView protein in Pfam
PF01488 Shikimate_DH, 1 hit
PF08501 Shikimate_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00507 aroE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TZ24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSVSVDAE TNVVGLIGHP VEHSLSPAMH NAAFKELGLN YVYLAFDVPP
60 70 80 90 100
ERLEGAVRGA ADLGIVGLNV TIPHKEAVME LCDELDRDAE LIGAVNTVRF
110 120 130 140 150
SRGKIEGFNT DGEGFLRALR EETYFDPRGT KSVILGAGGA ARAVSFKLAT
160 170 180 190 200
EGADEIVIAN RTVDRAERLA EELKEKVGVK ARAIGLDGDE IERELRDADL
210 220 230 240 250
LVDATPVGMY PNEDEPPLVT ADQMHEDLIV NDLVYNPPRT RLLEEAEKAG
260 270 280 290
ATPVSGVGML VYQGALAFEL WTGEEAPVEV MREAVLEHLR
Length:290
Mass (Da):31,413
Last modified:June 1, 2002 - v1
Checksum:iDA8DF9AEB739BBA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01334.1
PIRiS65949

Genome annotation databases

EnsemblBacteriaiAAM01334; AAM01334; MK0117
KEGGimka:MK0117
PATRICifig|190192.8.peg.116

Similar proteinsi

Entry informationi

Entry nameiAROE_METKA
AccessioniPrimary (citable) accession number: Q8TZ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health