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Q8TYX9 (PSD_METKA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:MK0162
OrganismMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifier190192 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000029827
Chain180 – 21435Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000029828

Sites

Site179 – 1802Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue1801Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TYX9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: FC9AC158CDB1FD94

FASTA21423,426
        10         20         30         40         50         60 
MMAPGWWKFV TPPAALGAAL FPWSRPLSFL CLGTAAFLAF FFRNPPREPP SDPSLAVSPA 

        70         80         90        100        110        120 
DGRLLGYVME AGEASDDELS SYLDDPITVS VFMSPLDVHV NRAPLDGRVV EAEILKGRFR 

       130        140        150        160        170        180 
PAFRKDSATE NNRAVLLFDG DPPFVVRLVS GAVARRIDLY VQEGDEVNKG EPIGMIRFGS 

       190        200        210 
RVDLAVPRSS VEELLVRKGD SVKAGETPVI RVKR

« Hide

References

[1]"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens."
Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A.
Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE009439 Genomic DNA. Translation: AAM01379.1.
RefSeqNP_613449.1. NC_003551.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1477465.
GenomeReviewsGene locus MK0162 in contig AE009439_GR.
KEGGmka:MK0162.
NMPDRfig|190192.1.peg.162.

Phylogenomic databases

HOGENOMHBG541103.
OMANERVVWH.
PhylomeDBQ8TYX9.
ProtClustDBPRK05305.

Enzyme and pathway databases

BioCycMKAN190192:MK0162-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_METKA
AccessionPrimary (citable) accession number: Q8TYX9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: June 1, 2002
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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