Q8TYV1 (CAPPA_METKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoenolpyruvate carboxylase
Short name=PEPC
Short name=PEPCase
EC=4.1.1.31

Gene names

Name:	ppcA
Ordered Locus Names:	MK0190

Organism

Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) [Reference proteome] [HAMAP]

Taxonomic identifier

190192 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus › Methanopyrus kandleri

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_01904
Catalytic activity	Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_01904
Cofactor	Magnesium By similarity.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the PEPCase type 2 family.

Ontologies

Keywords
Biological process	Carbon dioxide fixation
Ligand	Magnesium
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbon fixation Inferred from electronic annotation. Source: HAMAP oxaloacetate metabolic process Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoenolpyruvate carboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 532	532	Phosphoenolpyruvate carboxylase HAMAP-Rule MF_01904		PRO_0000309601

Sequences

	Sequence		Length	Mass (Da)
	Q8TYV1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 98E64A0E55D089C9	FASTA	532	59,778
	10 20 30 40 50 60 MEKVREARIA RTLATQHPDA TKFVRVQEEP EEAVECLVEL GAEEYMVDFE GKLTPYLQPI 70 80 90 100 110 120 QVLMELYDAG VRVGEERFVI VRVPSATKEN VLRQVQALLG VMEANSELLK EDPDARGIFE 130 140 150 160 170 180 VVHPMTSSPE ELVETVDRIS YARRFASREL DVPLKAGNLR IIPLIEEVPE LLDIRNILTG 190 200 210 220 230 240 YVEGMREIGM DVSYLRVFIG RSDPALSYGH LPAVLACKLA IFEVYELSDE LGVPMAPILG 250 260 270 280 290 300 GGCLPFRGHI RPGMEEEFVE EYAGTATYTV QSGFRYDHDR EKAVASIRRI NELAANDPLQ 310 320 330 340 350 360 LSGDDIEYLV LATAIFMKHY LSVFFRCIGT LNIVADMIPN TRDRLARKGP VGYARDIPEP 370 380 390 400 410 420 DRVGAQCKDL GDVGRELYRE LRRMRVEKLP ELPRAIKFTG ACYTVGMPPE LIGTGRGLAE 430 440 450 460 470 480 IEERLGEDAL DAVISRLYPM LREDLQFAVE YTFLETAGSV LPSSGVAMVN TDLEYCVEYL 490 500 510 520 530 DLEPPSDFEY QNLVHTLEPY LRYVVSEGGV EEVNPFVRDL LLEMGRMRGS LG

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009439 Genomic DNA. Translation: AAM01407.1.
RefSeq	NP_613477.1. NC_003551.1.
3D structure databases
ProteinModelPortal	Q8TYV1.
ModBase	Search...
Protein-protein interaction databases
STRING	190192.MK0190.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM01407; AAM01407; MK0190.
GeneID	1477493.
KEGG	mka:MK0190.
Phylogenomic databases
eggNOG	COG1892.
HOGENOM	HOG000009826.
KO	K01595.
OMA	MCTQHPD.
ProtClustDB	PRK13655.
Family and domain databases
HAMAP	MF_01904. PEPcase_type2.
InterPro	IPR007566. PEP_COase_arc-type. IPR015813. Pyrv/PenolPyrv_Kinase. [Graphical view]
PIRSF	PIRSF006677. UCP006677. 1 hit.
SUPFAM	SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMs	TIGR02751. PEPCase_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CAPPA_METKA

Accession

Primary (citable) accession number: Q8TYV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program