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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:MK0190
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Phosphoenolpyruvate carboxylasePRO_0000309601Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi190192.MK0190.

Structurei

3D structure databases

ProteinModelPortaliQ8TYV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000009826.
KOiK01595.
OMAiQSSFKYD.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TYV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVREARIA RTLATQHPDA TKFVRVQEEP EEAVECLVEL GAEEYMVDFE
60 70 80 90 100
GKLTPYLQPI QVLMELYDAG VRVGEERFVI VRVPSATKEN VLRQVQALLG
110 120 130 140 150
VMEANSELLK EDPDARGIFE VVHPMTSSPE ELVETVDRIS YARRFASREL
160 170 180 190 200
DVPLKAGNLR IIPLIEEVPE LLDIRNILTG YVEGMREIGM DVSYLRVFIG
210 220 230 240 250
RSDPALSYGH LPAVLACKLA IFEVYELSDE LGVPMAPILG GGCLPFRGHI
260 270 280 290 300
RPGMEEEFVE EYAGTATYTV QSGFRYDHDR EKAVASIRRI NELAANDPLQ
310 320 330 340 350
LSGDDIEYLV LATAIFMKHY LSVFFRCIGT LNIVADMIPN TRDRLARKGP
360 370 380 390 400
VGYARDIPEP DRVGAQCKDL GDVGRELYRE LRRMRVEKLP ELPRAIKFTG
410 420 430 440 450
ACYTVGMPPE LIGTGRGLAE IEERLGEDAL DAVISRLYPM LREDLQFAVE
460 470 480 490 500
YTFLETAGSV LPSSGVAMVN TDLEYCVEYL DLEPPSDFEY QNLVHTLEPY
510 520 530
LRYVVSEGGV EEVNPFVRDL LLEMGRMRGS LG
Length:532
Mass (Da):59,778
Last modified:June 1, 2002 - v1
Checksum:i98E64A0E55D089C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM01407.1.
RefSeqiNP_613477.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM01407; AAM01407; MK0190.
GeneIDi1477493.
KEGGimka:MK0190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM01407.1.
RefSeqiNP_613477.1. NC_003551.1.

3D structure databases

ProteinModelPortaliQ8TYV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK0190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM01407; AAM01407; MK0190.
GeneIDi1477493.
KEGGimka:MK0190.

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000009826.
KOiK01595.
OMAiQSSFKYD.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Entry informationi

Entry nameiCAPPA_METKA
AccessioniPrimary (citable) accession number: Q8TYV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: April 1, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.