Reviewed, UniProtKB/Swiss-Prot Q8TYT9 (PGP_METKA)

Names and origin

Protein names

Recommended name:
    Phosphoglycolate phosphatase
      Short name=PGPase
      Short name=PGP
    EC=3.1.3.18

Gene names

Ordered Locus Names:

MK0203

Organism

Methanopyrus kandleri [Complete proteome] [HAMAP]

Taxonomic identifier

2320 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of 2-phosphoglycolate By similarity.
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_01419
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the archaeal SPP-like hydrolase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Phosphoglycolate phosphatase HAMAP MF_01419		PRO_0000146718
Sites
	Active site	8	1	Nucleophile By similarity
	Metal binding	8	1	Magnesium By similarity
	Metal binding	10	1	Magnesium By similarity
	Metal binding	179	1	Magnesium By similarity
	Metal binding	183	1	Magnesium By similarity
	Binding site	156	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TYT9-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: BAF79060B3483660	FASTA	232	25,162
	10 20 30 40 50 60 MTSLVITDID GTITGDDRAV HLKCIRYLRE LQKRGIPVGI ATGNTLCYSR SAATLLGFEG 70 80 90 100 110 120 PLIAENGGIV AVDDEEISTV PEEDIELIQE AYRELRRRLG VRRTEPPGLR RTEVAIYRDV 130 140 150 160 170 180 PIEEVERVLD GLGYSGRIEV VDTGFAYHLK SKRVDKGKGL LVICERLGID PDDVVAIGDG 190 200 210 220 230 DNDAPLLKAA GLGVAPANAT ENVKRIADVV LDAENGEGVA TFLRKLLEEV DA

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010319 Genomic DNA. Translation: AAM01420.1.
RefSeq	NP_613490.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1477506.
GenomeReviews	Gene locus MK0203 in contig AE009439_GR.
KEGG	mka:MK0203.
NMPDR	fig|190192.1.peg.203.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8TYT9.
OMA	Q8TYT9. DEEWILW.
Enzyme and pathway databases
BioCyc	MKAN190192:MK0203-MON.
BRENDA	3.1.3.18. 7577.
Family and domain databases
HAMAP	MF_01419. [Tree]
InterPro	IPR001757. ATPase_P-typ_ion-transptr. IPR013200. HAD-SF_hydro-like_3. IPR006379. HAD-SF_hydro_IIB. IPR006382. SPPlik_hydro_arc. IPR006378. Suc_phosP. [Graphical view]
Pfam	PF08282. Hydrolase_3. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit. TIGR01487. SPP-like. 1 hit. TIGR01482. SPP-subfamily. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PGP_METKA

Accession

Primary (citable) accession number: Q8TYT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)