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Q8TYR3

- SPSS_METKA

UniProt

Q8TYR3 - SPSS_METKA

Protein

O-phospho-L-seryl-tRNA:Cys-tRNA synthase

Gene

MK0229

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).UniRule annotation

    Catalytic activityi

    O-phospho-L-seryl-tRNA(Cys) + sulfide = L-cysteinyl-tRNA(Cys) + phosphate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851Sulfur donor or Sep-tRNA(Cys)UniRule annotation
    Binding sitei109 – 1091Sulfur donor or Sep-tRNA(Cys)UniRule annotation
    Binding sitei110 – 1101Sulfur donor or Sep-tRNA(Cys)UniRule annotation
    Binding sitei191 – 1911Pyridoxal phosphateUniRule annotation
    Binding sitei283 – 2831Sulfur donor or Sep-tRNA(Cys)UniRule annotation
    Binding sitei292 – 2921Sulfur donor or Sep-tRNA(Cys)UniRule annotation

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. Sep-tRNA:Cys-tRNA synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    O-phospho-L-seryl-tRNA:Cys-tRNA synthaseUniRule annotation (EC:2.5.1.73UniRule annotation)
    Alternative name(s):
    Sep-tRNA:Cys-tRNA synthaseUniRule annotation
    Short name:
    SepCysSUniRule annotation
    Gene namesi
    Ordered Locus Names:MK0229
    OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
    Taxonomic identifieri190192 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
    ProteomesiUP000001826: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392O-phospho-L-seryl-tRNA:Cys-tRNA synthasePRO_0000359456Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei217 – 2171N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer. Interacts with SepRS.UniRule annotation

    Protein-protein interaction databases

    STRINGi190192.MK0229.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TYR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 852Pyridoxal phosphate bindingUniRule annotation
    Regioni214 – 2163Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the SepCysS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1103.
    HOGENOMiHOG000015511.
    KOiK06868.
    OMAiLILNTAY.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_01675. Sep_Cys_tRNA_synth.
    InterProiIPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR013375. Sep_Cys-tRNA_synth_arc.
    IPR008829. SLA/LP_auto_ag.
    [Graphical view]
    PfamiPF05889. SLA_LP_auto_ag. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR02539. SepCysS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8TYR3-1 [UniParc]FASTAAdd to Basket

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    MNLDRYRNIV RETERKYINV NPIQRGGVLT PEARKALLEF GDGYSVCDFC    50
    EGLLHEIEKP PIRQFHEDLA EFLGMDVVRI TAGARYAKEA VMSALCEEGD 100
    VVVADSLAHY TTFVAAEKAG ATVREVPNTG HPEYKVKVDE YARVIDEVED 150
    ERGDPPALAL LTHVDSEYGN LADAEKFVKI CRKKGVPALL NCAYTMGRMD 200
    LSNLSPKPDF MVGSGHKGMA ACAPCGVLAM REEWEEEVLR GSSLRGDVSG 250
    REWPHKEVEM LGCTVMGAPI VTMMASFPHV VERVKRWKEE VRKTRWFVKE 300
    MERIEGVRQL GERPKRHDLV KFETPGFHEV AEDHPRRGYF LYEELKKRGV 350
    IGIQPGQTET IKASVYGLTD EQVEHVVRAF HEIAEEYGLE VS 392
    Length:392
    Mass (Da):44,252
    Last modified:June 1, 2002 - v1
    Checksum:i28CFB3206D0621BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009439 Genomic DNA. Translation: AAM01446.1.
    RefSeqiNP_613516.1. NC_003551.1.
    WP_011018601.1. NC_003551.1.

    Genome annotation databases

    EnsemblBacteriaiAAM01446; AAM01446; MK0229.
    GeneIDi1477532.
    KEGGimka:MK0229.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009439 Genomic DNA. Translation: AAM01446.1 .
    RefSeqi NP_613516.1. NC_003551.1.
    WP_011018601.1. NC_003551.1.

    3D structure databases

    ProteinModelPortali Q8TYR3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190192.MK0229.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM01446 ; AAM01446 ; MK0229 .
    GeneIDi 1477532.
    KEGGi mka:MK0229.

    Phylogenomic databases

    eggNOGi COG1103.
    HOGENOMi HOG000015511.
    KOi K06868.
    OMAi LILNTAY.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_01675. Sep_Cys_tRNA_synth.
    InterProi IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR013375. Sep_Cys-tRNA_synth_arc.
    IPR008829. SLA/LP_auto_ag.
    [Graphical view ]
    Pfami PF05889. SLA_LP_auto_ag. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR02539. SepCysS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

    Entry informationi

    Entry nameiSPSS_METKA
    AccessioniPrimary (citable) accession number: Q8TYR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3