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Q8TYP4

- HDRA1_METKA

UniProt

Q8TYP4 - HDRA1_METKA

Protein

CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1

Gene

hdrA1

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit By similarity.By similarity

    Catalytic activityi

    Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine.

    Cofactori

    Binds 4 4Fe-4S clusters per subunit.By similarity
    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi249 – 2491Iron-sulfur 1 (4Fe-4S)Sequence Analysis
    Metal bindingi252 – 2521Iron-sulfur 1 (4Fe-4S)Sequence Analysis
    Metal bindingi255 – 2551Iron-sulfur 1 (4Fe-4S)Sequence Analysis
    Metal bindingi259 – 2591Iron-sulfur 2 (4Fe-4S)Sequence Analysis
    Metal bindingi296 – 2961Iron-sulfur 2 (4Fe-4S)Sequence Analysis
    Metal bindingi299 – 2991Iron-sulfur 2 (4Fe-4S)Sequence Analysis
    Metal bindingi302 – 3021Iron-sulfur 2 (4Fe-4S)Sequence Analysis
    Metal bindingi306 – 3061Iron-sulfur 1 (4Fe-4S)Sequence Analysis
    Metal bindingi593 – 5931Iron-sulfur 3 (4Fe-4S)Sequence Analysis
    Metal bindingi596 – 5961Iron-sulfur 3 (4Fe-4S)Sequence Analysis
    Metal bindingi599 – 5991Iron-sulfur 3 (4Fe-4S)Sequence Analysis
    Metal bindingi603 – 6031Iron-sulfur 4 (4Fe-4S)Sequence Analysis
    Metal bindingi626 – 6261Iron-sulfur 4 (4Fe-4S)Sequence Analysis
    Metal bindingi629 – 6291Iron-sulfur 4 (4Fe-4S)Sequence Analysis
    Metal bindingi632 – 6321Iron-sulfur 4 (4Fe-4S)Sequence Analysis
    Metal bindingi636 – 6361Iron-sulfur 3 (4Fe-4S)Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi153 – 17624FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. CoB--CoM heterodisulfide reductase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. methanogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Methanogenesis

    Keywords - Ligandi

    4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00647; UER00700.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1 (EC:1.8.98.1)
    Gene namesi
    Name:hdrA1
    Synonyms:hdrA_1
    Ordered Locus Names:MK0249
    OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
    Taxonomic identifieri190192 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
    ProteomesiUP000001826: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 669669CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1PRO_0000150058Add
    BLAST

    Interactioni

    Subunit structurei

    The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.By similarity

    Protein-protein interaction databases

    STRINGi190192.MK0249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TYP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini239 – 270324Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini287 – 318324Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini584 – 613304Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini617 – 646304Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HdrA family.Curated
    Contains 4 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1148.
    HOGENOMiHOG000230698.
    KOiK03388.
    OMAiCTPKIHE.

    Family and domain databases

    InterProiIPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    [Graphical view]
    PfamiPF00037. Fer4. 2 hits.
    PF12838. Fer4_7. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    [Graphical view]
    PROSITEiPS00198. 4FE4S_FER_1. 4 hits.
    PS51379. 4FE4S_FER_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TYP4-1 [UniParc]FASTAAdd to Basket

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    MGDKDDVRIG VFVCHCGVNI KASVDVEEVV EYAKKLPGVV YATDYPFFCA    50
    DPGQEIIQEA IKEHDLDRVV VAACTPKIHE NTFRNCVKEA GLSPYYMEMV 100
    NIREHCSFVH MQEPEKATEK AKDLIRAAVE RAKRLEDVPT KEVEVENSVL 150
    IIGGGIAGIQ AALDLADQGF KVYLVEKEPT IGGNMARLAK TFPTDDCAMU 200
    ILAPKMVQVG NHPNIEMITY AEVKDVDGYI GNFEVTIEKK PRYVDEDACT 250
    GCGVCAEVCP IEVPNEFDLG IGTRKAIYVP FPQAMPLVYT IDMEHCIQCG 300
    LCEEACPQDP PAIDFDQEPE EIRLKVGTII VATGYEEFDA SKLEEYGYGK 350
    YDNVITTLEL ERMINPAGPT EGHVIRPSDG KEPHRIVFIH CVGSRCPGKE 400
    EKGEAYCSRI CCMFILKNAQ LIKQHEPDAE VYCCYMDVRA FGKGYEEYYE 450
    RAQKQFGVRF IRGRPAEIVE DPETKNLIVR VEDTLTGEPM EIEADLVVLG 500
    CGLVAPEETY SKLADILGID RSPDGFFKEL HPKLEPVSTK VRGVQIAGVA 550
    QGPKDIPDTV AQAKGAASEA SIPMSQGKVE IELITATVDE DVCGGCGACA 600
    QVCPFDAIEM VEKDGKRVAE VQDVACQGCG QCAAACPSGA MQLRYYRDEQ 650
    LMPQIEALLA EALEEEEEE 669
    Length:669
    Mass (Da):73,742
    Last modified:February 26, 2008 - v3
    Checksum:iC2D8D120157026E5
    GO

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei200 – 2001SelenocysteineCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009439 Genomic DNA. Translation: AAM01466.1.
    RefSeqiNP_613536.1. NC_003551.1.
    WP_011018621.1. NC_003551.1.

    Genome annotation databases

    EnsemblBacteriaiAAM01466; AAM01466; MK0249.
    GeneIDi1477552.
    KEGGimka:MK0249.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009439 Genomic DNA. Translation: AAM01466.1 .
    RefSeqi NP_613536.1. NC_003551.1.
    WP_011018621.1. NC_003551.1.

    3D structure databases

    ProteinModelPortali Q8TYP4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190192.MK0249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM01466 ; AAM01466 ; MK0249 .
    GeneIDi 1477552.
    KEGGi mka:MK0249.

    Phylogenomic databases

    eggNOGi COG1148.
    HOGENOMi HOG000230698.
    KOi K03388.
    OMAi CTPKIHE.

    Enzyme and pathway databases

    UniPathwayi UPA00647 ; UER00700 .

    Family and domain databases

    InterProi IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    [Graphical view ]
    Pfami PF00037. Fer4. 2 hits.
    PF12838. Fer4_7. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    [Graphical view ]
    PROSITEi PS00198. 4FE4S_FER_1. 4 hits.
    PS51379. 4FE4S_FER_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

    Entry informationi

    Entry nameiHDRA1_METKA
    AccessioniPrimary (citable) accession number: Q8TYP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3