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Q8TYP4

- HDRA1_METKA

UniProt

Q8TYP4 - HDRA1_METKA

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Protein

CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1

Gene

hdrA1

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit By similarity.By similarity

Catalytic activityi

Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine.

Cofactori

Binds 4 4Fe-4S clusters per subunit.By similarity
FAD.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi249 – 2491Iron-sulfur 1 (4Fe-4S)Sequence Analysis
Metal bindingi252 – 2521Iron-sulfur 1 (4Fe-4S)Sequence Analysis
Metal bindingi255 – 2551Iron-sulfur 1 (4Fe-4S)Sequence Analysis
Metal bindingi259 – 2591Iron-sulfur 2 (4Fe-4S)Sequence Analysis
Metal bindingi296 – 2961Iron-sulfur 2 (4Fe-4S)Sequence Analysis
Metal bindingi299 – 2991Iron-sulfur 2 (4Fe-4S)Sequence Analysis
Metal bindingi302 – 3021Iron-sulfur 2 (4Fe-4S)Sequence Analysis
Metal bindingi306 – 3061Iron-sulfur 1 (4Fe-4S)Sequence Analysis
Metal bindingi593 – 5931Iron-sulfur 3 (4Fe-4S)Sequence Analysis
Metal bindingi596 – 5961Iron-sulfur 3 (4Fe-4S)Sequence Analysis
Metal bindingi599 – 5991Iron-sulfur 3 (4Fe-4S)Sequence Analysis
Metal bindingi603 – 6031Iron-sulfur 4 (4Fe-4S)Sequence Analysis
Metal bindingi626 – 6261Iron-sulfur 4 (4Fe-4S)Sequence Analysis
Metal bindingi629 – 6291Iron-sulfur 4 (4Fe-4S)Sequence Analysis
Metal bindingi632 – 6321Iron-sulfur 4 (4Fe-4S)Sequence Analysis
Metal bindingi636 – 6361Iron-sulfur 3 (4Fe-4S)Sequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi153 – 17624FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. CoB--CoM heterodisulfide reductase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. methanogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Methanogenesis

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00647; UER00700.

Names & Taxonomyi

Protein namesi
Recommended name:
CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1 (EC:1.8.98.1)
Gene namesi
Name:hdrA1
Synonyms:hdrA_1
Ordered Locus Names:MK0249
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1PRO_0000150058Add
BLAST

Interactioni

Subunit structurei

The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.By similarity

Protein-protein interaction databases

STRINGi190192.MK0249.

Structurei

3D structure databases

ProteinModelPortaliQ8TYP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini239 – 270324Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini287 – 318324Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini584 – 613304Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini617 – 646304Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HdrA family.Curated
Contains 4 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1148.
HOGENOMiHOG000230698.
KOiK03388.
OMAiCTPKIHE.

Family and domain databases

InterProiIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
[Graphical view]
PfamiPF00037. Fer4. 2 hits.
PF12838. Fer4_7. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PROSITEiPS00198. 4FE4S_FER_1. 4 hits.
PS51379. 4FE4S_FER_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TYP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDKDDVRIG VFVCHCGVNI KASVDVEEVV EYAKKLPGVV YATDYPFFCA
60 70 80 90 100
DPGQEIIQEA IKEHDLDRVV VAACTPKIHE NTFRNCVKEA GLSPYYMEMV
110 120 130 140 150
NIREHCSFVH MQEPEKATEK AKDLIRAAVE RAKRLEDVPT KEVEVENSVL
160 170 180 190 200
IIGGGIAGIQ AALDLADQGF KVYLVEKEPT IGGNMARLAK TFPTDDCAMU
210 220 230 240 250
ILAPKMVQVG NHPNIEMITY AEVKDVDGYI GNFEVTIEKK PRYVDEDACT
260 270 280 290 300
GCGVCAEVCP IEVPNEFDLG IGTRKAIYVP FPQAMPLVYT IDMEHCIQCG
310 320 330 340 350
LCEEACPQDP PAIDFDQEPE EIRLKVGTII VATGYEEFDA SKLEEYGYGK
360 370 380 390 400
YDNVITTLEL ERMINPAGPT EGHVIRPSDG KEPHRIVFIH CVGSRCPGKE
410 420 430 440 450
EKGEAYCSRI CCMFILKNAQ LIKQHEPDAE VYCCYMDVRA FGKGYEEYYE
460 470 480 490 500
RAQKQFGVRF IRGRPAEIVE DPETKNLIVR VEDTLTGEPM EIEADLVVLG
510 520 530 540 550
CGLVAPEETY SKLADILGID RSPDGFFKEL HPKLEPVSTK VRGVQIAGVA
560 570 580 590 600
QGPKDIPDTV AQAKGAASEA SIPMSQGKVE IELITATVDE DVCGGCGACA
610 620 630 640 650
QVCPFDAIEM VEKDGKRVAE VQDVACQGCG QCAAACPSGA MQLRYYRDEQ
660
LMPQIEALLA EALEEEEEE
Length:669
Mass (Da):73,742
Last modified:February 26, 2008 - v3
Checksum:iC2D8D120157026E5
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei200 – 2001SelenocysteineCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM01466.1.
RefSeqiNP_613536.1. NC_003551.1.
WP_011018621.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM01466; AAM01466; MK0249.
GeneIDi1477552.
KEGGimka:MK0249.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM01466.1 .
RefSeqi NP_613536.1. NC_003551.1.
WP_011018621.1. NC_003551.1.

3D structure databases

ProteinModelPortali Q8TYP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190192.MK0249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM01466 ; AAM01466 ; MK0249 .
GeneIDi 1477552.
KEGGi mka:MK0249.

Phylogenomic databases

eggNOGi COG1148.
HOGENOMi HOG000230698.
KOi K03388.
OMAi CTPKIHE.

Enzyme and pathway databases

UniPathwayi UPA00647 ; UER00700 .

Family and domain databases

InterProi IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
[Graphical view ]
Pfami PF00037. Fer4. 2 hits.
PF12838. Fer4_7. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view ]
PROSITEi PS00198. 4FE4S_FER_1. 4 hits.
PS51379. 4FE4S_FER_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Entry informationi

Entry nameiHDRA1_METKA
AccessioniPrimary (citable) accession number: Q8TYP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: February 26, 2008
Last modified: October 1, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3