Q8TYK5 (DCD_METKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	MK0291

Organism

Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)

Taxonomic identifier

190192 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Probable deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_0000156030

Sequences

	Sequence		Length	Mass (Da)
	Q8TYK5 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: F3CAD69C62DD3168	FASTA	193	21,593
	10 20 30 40 50 60 MTVLSDRDIK RALEEGDIVV KPLEEEYLEE ALGPASLDLR LGNEFVVFKT LHKPCIDPTV 70 80 90 100 110 120 DAGENTERIV IDEDEEFVIN PGELVLAVTH EWIEINAPDI TGVLHGRSSL GRLGIQAHVE 130 140 150 160 170 180 AGYVDPGWRG RLTLELVNFN PMPVKLRPGM RVVQIVFHRL SSPAERTYAE SSGKYHGDER 190 PSPSKMHLDF CRG

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009439 Genomic DNA. Translation: AAM01508.1.
RefSeq	NP_613578.1. NC_003551.1.
3D structure databases
ProteinModelPortal	Q8TYK5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1477594.
GenomeReviews	Gene locus MK0291 in contig AE009439_GR.
KEGG	mka:MK0291.
NMPDR	fig|190192.1.peg.291.
Phylogenomic databases
HOGENOM	HBG553199.
OMA	HTAAYID.
PhylomeDB	Q8TYK5.
Enzyme and pathway databases
BioCyc	MKAN190192:MK0291-MONOMER.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
KO	K01494.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. DCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_METKA

Accession

Primary (citable) accession number: Q8TYK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program