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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MK0343
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367241 – 374Tryptophan--tRNA ligaseAdd BLAST374

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0343

Structurei

3D structure databases

ProteinModelPortaliQ8TYF7
SMRiQ8TYF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi71 – 79"HIGH" region9
Motifi247 – 251"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224743
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TYF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDPWDVEEV DYERLTEEFG IRPIDEKVRE LLPRRFPLLD RGIVFGHRDY
60 70 80 90 100
DSFLKDYNDG KLVSVLSGMM PSGRMHLGHK TVVDQLVFYQ QEMDVKVYVP
110 120 130 140 150
IADLEAHHAR NMDLDRAHRI AVEEYVLNYA ALGLDLDPDR CEIYLQSERK
160 170 180 190 200
TVQRMALLLA GRLTWNTVKN TYGFTGETNM GHAFAPIVQA ADILHPQEIE
210 220 230 240 250
GPHRVLVPVG VDQDPHLRLT RDIAEKEDLI KPASTYHRFM TGLTGGKMSS
260 270 280 290 300
SKPNTAIFLT DDPETAKEKV WNAKTGGGAT LEEHREHGGN PDECVVYELM
310 320 330 340 350
VYHLADRIGG DEKLREIRKK CREGDIICGE CKRMVGEALA EILEELERRR
360 370
EDVRDELPDL LSQHPDAPEV PEDW
Length:374
Mass (Da):42,733
Last modified:June 1, 2002 - v1
Checksum:i0BD4E5279321B828
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01558.1

Genome annotation databases

EnsemblBacteriaiAAM01558; AAM01558; MK0343
KEGGimka:MK0343
PATRICifig|190192.8.peg.364

Entry informationi

Entry nameiSYW_METKA
AccessioniPrimary (citable) accession number: Q8TYF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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