Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MK0343
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Tryptophan--tRNA ligasePRO_0000136724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0343.

Structurei

3D structure databases

ProteinModelPortaliQ8TYF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi71 – 799"HIGH" region
Motifi247 – 2515"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.
OMAiKPETAIY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TYF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDPWDVEEV DYERLTEEFG IRPIDEKVRE LLPRRFPLLD RGIVFGHRDY
60 70 80 90 100
DSFLKDYNDG KLVSVLSGMM PSGRMHLGHK TVVDQLVFYQ QEMDVKVYVP
110 120 130 140 150
IADLEAHHAR NMDLDRAHRI AVEEYVLNYA ALGLDLDPDR CEIYLQSERK
160 170 180 190 200
TVQRMALLLA GRLTWNTVKN TYGFTGETNM GHAFAPIVQA ADILHPQEIE
210 220 230 240 250
GPHRVLVPVG VDQDPHLRLT RDIAEKEDLI KPASTYHRFM TGLTGGKMSS
260 270 280 290 300
SKPNTAIFLT DDPETAKEKV WNAKTGGGAT LEEHREHGGN PDECVVYELM
310 320 330 340 350
VYHLADRIGG DEKLREIRKK CREGDIICGE CKRMVGEALA EILEELERRR
360 370
EDVRDELPDL LSQHPDAPEV PEDW
Length:374
Mass (Da):42,733
Last modified:June 1, 2002 - v1
Checksum:i0BD4E5279321B828
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM01558.1.
RefSeqiNP_613628.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM01558; AAM01558; MK0343.
GeneIDi1477646.
KEGGimka:MK0343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM01558.1.
RefSeqiNP_613628.1. NC_003551.1.

3D structure databases

ProteinModelPortaliQ8TYF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK0343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM01558; AAM01558; MK0343.
GeneIDi1477646.
KEGGimka:MK0343.

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.
OMAiKPETAIY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Entry informationi

Entry nameiSYW_METKA
AccessioniPrimary (citable) accession number: Q8TYF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: February 4, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.