Reviewed, UniProtKB/Swiss-Prot Q8TYB5 (RNP3_METKA)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein component 3
      Short name=RNase P component 3
    EC=3.1.26.5

Gene names

Name:	rnp3
Ordered Locus Names:	MK0387

Organism

Methanopyrus kandleri [Complete proteome] [HAMAP]

Taxonomic identifier

2320 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity. HAMAP MF_00756
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00756
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential. HAMAP MF_00756
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	Ribonuclease P protein component 3 HAMAP MF_00756		PRO_0000140040

Sequences

	Sequence		Length	Mass (Da)
	Q8TYB5-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 10F8CBBD23D0AD2F	FASTA	244	28,043
	10 20 30 40 50 60 MRVSENFALR VHVDEVDPLR MALAAERLDY EIAVLCLELE AERLNIDDLR WLIEEIRDIR 70 80 90 100 110 120 EHVESVLVLP GCKLEAESAG ALRRAIRRTR PLVYLLAVGG GDPKINRAAV SDTRVDLLSH 130 140 150 160 170 180 PERGNPHAGL GKYEIELARE KWTYVEIDLS RLFRREGERL AWQVSRIRDL LRLRRRKRFP 190 200 210 220 230 240 TTVALGARDP LELIRPKQVE DLLKLMGFED SEVKEMCVEA PREILRWNAA CKHVFTVPGV VSLG

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009439 Genomic DNA. Translation: AAM01602.1.
RefSeq	NP_613672.1.
3D structure databases
SMR	Q8TYB5. Positions 71-226.
ModBase	Search...
Genome annotation databases
GeneID	1477690.
GenomeReviews	Gene locus MK0387 in contig AE009439_GR.
KEGG	mka:MK0387.
NMPDR	fig|190192.1.peg.385.
Organism-specific databases
CMR	Search...
Enzyme and pathway databases
BioCyc	MKAN190192:MK0387-MONOMER.
BRENDA	3.1.26.5. 7577.
Family and domain databases
HAMAP	MF_00756. RNase_P_3. [Tree]
InterPro	IPR016195. Pol/histidinol_Pase-like. IPR002738. RNase_P_p30. [Graphical view]
Pfam	PF01876. RNase_P_p30. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNP3_METKA

Accession

Primary (citable) accession number: Q8TYB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)