Q8TXN9 (ARLY_METKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	MK0622

Organism

Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)

Taxonomic identifier

190192 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137863

Sequences

	Sequence		Length	Mass (Da)
	Q8TXN9 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 2838F8287E0ABE68	FASTA	508	55,635
	10 20 30 40 50 60 MALGRPSYRG GRVSGGRDPD FAELSSSLEQ DREIFHCDVW NSVVHAVSLW EAGRIDRSTA 70 80 90 100 110 120 AGIVEGLVTV LEEGPDRLPE DAEDVHEAIE SRLHEVVGEE AGWLQLGRSR NDQVATSVRM 130 140 150 160 170 180 RLRERALDLS RELVGLGRAL LDLAREHAEV PIAGYTHLKR AQPCTIGFWM STYAAAVARS 190 200 210 220 230 240 ARGLLRVPGM DECPLGCSAF PGSTVPVDRH REAALLGFRK PARHCGEATA LRGPILEFLG 250 260 270 280 290 300 RLATAASELT RLAGDLIQLC SDELGVVEPP DELSSTSSVM PHKKNPDALE LVRAELTVVA 310 320 330 340 350 360 GLKGLGDAVH GKLPMFYNRD LQVLNGLLWD SVNRFELCVR VLRKVVEGLD VDEEAARGTV 370 380 390 400 410 420 LGSHAAAVDL AELVAERAGL TFREAHKVVG RVSARLDREG VPMSPERADR VVEELEREGV 430 440 450 460 470 480 KLRVEEVREV LSLKRTLRRP VEGSTDPGRL EVTLDRLRAE LAAAERLEGT WRGRIERALR 490 500 ATEAAVNRLG VEGFAEVYRG YWDGEAPG

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009439 Genomic DNA. Translation: AAM01837.1.
RefSeq	NP_613907.1. NC_003551.1.
3D structure databases
ProteinModelPortal	Q8TXN9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1476723.
GenomeReviews	Gene locus MK0622 in contig AE009439_GR.
KEGG	mka:MK0622.
NMPDR	fig|190192.1.peg.620.
Phylogenomic databases
HOGENOM	HBG539632.
OMA	EDIHTVI.
PhylomeDB	Q8TXN9.
Enzyme and pathway databases
BioCyc	MKAN190192:MK0622-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_METKA

Accession

Primary (citable) accession number: Q8TXN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program