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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

MK0642

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19MagnesiumUniRule annotation1
Metal bindingi48MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMKAN190192:G139I-662-MONOMER
UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)
Short name:
GGGP synthaseUniRule annotation
Short name:
GGGPSUniRule annotation
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Phosphoglycerol geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:MK0642
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001387331 – 239Geranylgeranylglyceryl phosphate synthaseAdd BLAST239

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0642

Structurei

3D structure databases

ProteinModelPortaliQ8TXM0
SMRiQ8TXM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni167 – 173Glycerol-1-phosphate bindingUniRule annotation7
Regioni197 – 198Glycerol-1-phosphate bindingUniRule annotation2
Regioni219 – 220Glycerol-1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family. Group II subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01085 Archaea
COG1646 LUCA
HOGENOMiHOG000034117
KOiK17104
OMAiADAIFFM
OrthoDBiPOG093Z0C46

Family and domain databases

CDDicd02812 PcrB_like, 1 hit
Gene3Di3.20.20.390, 1 hit
HAMAPiMF_00112 GGGP_HepGP_synthase, 1 hit
InterProiView protein in InterPro
IPR038597 GGGP/HepGP_synthase_sf
IPR008205 GGGP_HepGP_synthase
IPR010946 GGGP_synth
PfamiView protein in Pfam
PF01884 PcrB, 1 hit
TIGRFAMsiTIGR01769 GGGP, 1 hit
TIGR01768 GGGP-family, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TXM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFGYLRER TPCHLTLLDP VDVGPEEVPE VLESLVKAGT DAVMVGGSTA
60 70 80 90 100
HASQVEAVVE AIREVADVPV ILFPNGPEGL APNADAVLFM SLLNSRNTYY
110 120 130 140 150
LIEAQVKGAP LVERFGLESI PTGYLIVGEW GTTVSVVGDA RVIPFDRVEV
160 170 180 190 200
IVAYALAAKH LGMKAVYLEA GSGAPEPVPP EVVRRVSGIG VFTIVGGGIR
210 220 230
SPETARELAE AGADAIVTGT AVERDPDLAA EIVEAIKDL
Length:239
Mass (Da):25,052
Last modified:June 1, 2002 - v1
Checksum:i179093DDD7872137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01857.1

Genome annotation databases

EnsemblBacteriaiAAM01857; AAM01857; MK0642
KEGGimka:MK0642
PATRICifig|190192.8.peg.681

Entry informationi

Entry nameiGGGPS_METKA
AccessioniPrimary (citable) accession number: Q8TXM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health