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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127NADUniRule annotation1
Binding sitei190NADUniRule annotation1
Binding sitei213NADUniRule annotation1
Binding sitei238SubstrateUniRule annotation1
Metal bindingi260ZincUniRule annotation1
Binding sitei260SubstrateUniRule annotation1
Metal bindingi263ZincUniRule annotation1
Binding sitei263SubstrateUniRule annotation1
Active sitei329Proton acceptorUniRule annotation1
Active sitei330Proton acceptorUniRule annotation1
Binding sitei330SubstrateUniRule annotation1
Metal bindingi363ZincUniRule annotation1
Binding sitei363SubstrateUniRule annotation1
Binding sitei417SubstrateUniRule annotation1
Metal bindingi422ZincUniRule annotation1
Binding sitei422SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:MK0711
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358951 – 431Histidinol dehydrogenaseAdd BLAST431

Proteomic databases

PRIDEiQ8TXG3

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0711

Structurei

3D structure databases

ProteinModelPortaliQ8TXG3
SMRiQ8TXG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04352 Archaea
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG093Z04GH

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TXG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLVRPEEE ELERVLRRSE MDVTEVLPDV ERIFEDVVER GDEALLEYTE
60 70 80 90 100
RFDGVKLEAE DLRVSEDDFE VARELVDERT VEALEEAAHR IEEFHRKTLP
110 120 130 140 150
RVDRITFDVE GTECGLTLRP IPRVGCYVPG GRAAYPSTAL MTVIPARVAG
160 170 180 190 200
CREVVVCTPP ADNDVRASPE VLVAVEIAGA DAVYRVGGAQ AIAALAAGTE
210 220 230 240 250
TVLRVDKIVG PGNVYVTAAK LLAYSRGLTD VDMPAGPSEV FVIADDSANP
260 270 280 290 300
DWLARDLIAQ AEHDPHAAAV LATDSEEIAR AVKERVEELL DAGIEREEIV
310 320 330 340 350
LKALDRNGWI VVLDSLEECV RLANRYAPEH LQLCVENPEE LLQDVENAGA
360 370 380 390 400
VFVGHLTAVP FGDYATGPNH VLPTGGFARA RGALGTWDFV KIIPIQRLRE
410 420 430
GDVERLAPIV EELAEREGLP NHAEAVRARR S
Length:431
Mass (Da):47,335
Last modified:June 1, 2002 - v1
Checksum:i50DD46829C9EB5DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01925.1

Genome annotation databases

EnsemblBacteriaiAAM01925; AAM01925; MK0711
KEGGimka:MK0711
PATRICifig|190192.8.peg.752

Entry informationi

Entry nameiHISX_METKA
AccessioniPrimary (citable) accession number: Q8TXG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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