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Q8TXG3

- HISX_METKA

UniProt

Q8TXG3 - HISX_METKA

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Protein
Histidinol dehydrogenase
Gene
hisD, MK0711
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei190 – 1901NAD By similarity
Binding sitei213 – 2131NAD By similarity
Binding sitei238 – 2381Substrate By similarity
Metal bindingi260 – 2601Zinc By similarity
Binding sitei260 – 2601Substrate By similarity
Metal bindingi263 – 2631Zinc By similarity
Binding sitei263 – 2631Substrate By similarity
Active sitei329 – 3291Proton acceptor By similarity
Active sitei330 – 3301Proton acceptor By similarity
Binding sitei330 – 3301Substrate By similarity
Metal bindingi363 – 3631Zinc By similarity
Binding sitei363 – 3631Substrate By similarity
Binding sitei417 – 4171Substrate By similarity
Metal bindingi422 – 4221Zinc By similarity
Binding sitei422 – 4221Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MK0711
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenaseUniRule annotation
PRO_0000135895Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0711.

Structurei

3D structure databases

ProteinModelPortaliQ8TXG3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiNAMSILL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TXG3-1 [UniParc]FASTAAdd to Basket

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MRLLVRPEEE ELERVLRRSE MDVTEVLPDV ERIFEDVVER GDEALLEYTE    50
RFDGVKLEAE DLRVSEDDFE VARELVDERT VEALEEAAHR IEEFHRKTLP 100
RVDRITFDVE GTECGLTLRP IPRVGCYVPG GRAAYPSTAL MTVIPARVAG 150
CREVVVCTPP ADNDVRASPE VLVAVEIAGA DAVYRVGGAQ AIAALAAGTE 200
TVLRVDKIVG PGNVYVTAAK LLAYSRGLTD VDMPAGPSEV FVIADDSANP 250
DWLARDLIAQ AEHDPHAAAV LATDSEEIAR AVKERVEELL DAGIEREEIV 300
LKALDRNGWI VVLDSLEECV RLANRYAPEH LQLCVENPEE LLQDVENAGA 350
VFVGHLTAVP FGDYATGPNH VLPTGGFARA RGALGTWDFV KIIPIQRLRE 400
GDVERLAPIV EELAEREGLP NHAEAVRARR S 431
Length:431
Mass (Da):47,335
Last modified:June 1, 2002 - v1
Checksum:i50DD46829C9EB5DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM01925.1.
RefSeqiNP_613995.1. NC_003551.1.
WP_011019080.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM01925; AAM01925; MK0711.
GeneIDi1476812.
KEGGimka:MK0711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM01925.1 .
RefSeqi NP_613995.1. NC_003551.1.
WP_011019080.1. NC_003551.1.

3D structure databases

ProteinModelPortali Q8TXG3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190192.MK0711.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM01925 ; AAM01925 ; MK0711 .
GeneIDi 1476812.
KEGGi mka:MK0711.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi NAMSILL.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Entry informationi

Entry nameiHISX_METKA
AccessioniPrimary (citable) accession number: Q8TXG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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