Q8TXD4 (PDAD_METKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvoyl-dependent arginine decarboxylase
Short name=PvlArgDC
EC=4.1.1.19

Cleaved into the following 2 chains:

1. Pyruvoyl-dependent arginine decarboxylase subunit beta
2. Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	pdaD
Ordered Locus Names:	MK0740

Organism

Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)

Taxonomic identifier

190192 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity. HAMAP MF_01404
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 41	41	Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity		PRO_0000023316
	Chain	42 – 150	109	Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity		PRO_0000023317
Sites
	Site	41 – 42	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	42	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TXD4 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 8FBA7ED4CCB07181	FASTA	150	15,596
	10 20 30 40 50 60 MGVPKKYALV SGTGEADTSL AAFDAALIDA GIGDCNLVEL SSILPPNAEE DDLPEFPPGS 70 80 90 100 110 120 IVPAVVAKAV GRGLVSSCIC VGRLESGLGI VSERAATDSV ETVRRLAKRD VEEMARLRGE 130 140 150 KLVEVRTVTA STEPEDAEWA AAVAAVVFWG

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009439 Genomic DNA. Translation: AAM01954.1.
RefSeq	NP_614024.1. NC_003551.1.
3D structure databases
ProteinModelPortal	Q8TXD4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1476841.
GenomeReviews	Gene locus MK0740 in contig AE009439_GR.
KEGG	mka:MK0740.
NMPDR	fig|190192.1.peg.737.
Phylogenomic databases
HOGENOM	HBG539680.
Enzyme and pathway databases
BioCyc	MKAN190192:MK0740-MONOMER.
Family and domain databases
HAMAP	MF_01404. PvlArgDC. [Tree]
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
KO	K02626.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56271. His_carbxylase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD_METKA

Accession

Primary (citable) accession number: Q8TXD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	June 1, 2002
Last modified:	November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program