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Protein

Pyruvoyl-dependent arginine decarboxylase

Gene

pdaD

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

pyruvateUniRule annotationNote: Binds 1 pyruvoyl group covalently per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyruvate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvoyl-dependent arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
PvlArgDCUniRule annotation
Cleaved into the following 2 chains:
Pyruvoyl-dependent arginine decarboxylase subunit betaUniRule annotation
Pyruvoyl-dependent arginine decarboxylase subunit alphaUniRule annotation
Gene namesi
Name:pdaDUniRule annotation
Ordered Locus Names:MK0740
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000233161 – 41Pyruvoyl-dependent arginine decarboxylase subunit betaUniRule annotationAdd BLAST41
ChainiPRO_000002331742 – 150Pyruvoyl-dependent arginine decarboxylase subunit alphaUniRule annotationAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42Pyruvic acid (Ser)UniRule annotation1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41 – 42Cleavage (non-hydrolytic)UniRule annotation2

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0740.

Structurei

3D structure databases

ProteinModelPortaliQ8TXD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdaD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04490. Archaea.
COG1945. LUCA.
HOGENOMiHOG000012204.
KOiK02626.
OMAiRDVEEMA.
OrthoDBiPOG093Z0D0B.

Family and domain databases

Gene3Di3.50.20.10. 1 hit.
HAMAPiMF_01404. PvlArgDC. 1 hit.
InterProiView protein in InterPro
IPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
PfamiView protein in Pfam
PF01862. PvlArgDC. 1 hit.
PIRSFiPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
SUPFAMiSSF56271. SSF56271. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TXD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPKKYALV SGTGEADTSL AAFDAALIDA GIGDCNLVEL SSILPPNAEE
60 70 80 90 100
DDLPEFPPGS IVPAVVAKAV GRGLVSSCIC VGRLESGLGI VSERAATDSV
110 120 130 140 150
ETVRRLAKRD VEEMARLRGE KLVEVRTVTA STEPEDAEWA AAVAAVVFWG
Length:150
Mass (Da):15,596
Last modified:June 1, 2002 - v1
Checksum:i8FBA7ED4CCB07181
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM01954.1.

Genome annotation databases

EnsemblBacteriaiAAM01954; AAM01954; MK0740.
KEGGimka:MK0740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM01954.1.

3D structure databases

ProteinModelPortaliQ8TXD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK0740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM01954; AAM01954; MK0740.
KEGGimka:MK0740.

Phylogenomic databases

eggNOGiarCOG04490. Archaea.
COG1945. LUCA.
HOGENOMiHOG000012204.
KOiK02626.
OMAiRDVEEMA.
OrthoDBiPOG093Z0D0B.

Family and domain databases

Gene3Di3.50.20.10. 1 hit.
HAMAPiMF_01404. PvlArgDC. 1 hit.
InterProiView protein in InterPro
IPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
PfamiView protein in Pfam
PF01862. PvlArgDC. 1 hit.
PIRSFiPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
SUPFAMiSSF56271. SSF56271. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDAD_METKA
AccessioniPrimary (citable) accession number: Q8TXD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2002
Last modified: February 15, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.