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Protein

NAD kinase

Gene

nadK

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1
Binding sitei73NADUniRule annotation1
Binding sitei149NADUniRule annotation1
Binding sitei168NADUniRule annotation1
Binding sitei237NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 69NADUniRule annotation2
Nucleotide bindingi138 – 139NADUniRule annotation2
Nucleotide bindingi179 – 184NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:MK0742
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207011 – 276NAD kinaseAdd BLAST276

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0742

Structurei

3D structure databases

ProteinModelPortaliQ8TXD2
SMRiQ8TXD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01348 Archaea
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TXD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRPQVVGVT GRTDLGRAVR VAERVCRLCD REGFEVLVDD SLGIGEYPRV
60 70 80 90 100
NLKDMGKEVD MIITIGGDGT ILRVSRITSE YEVPILGVNL GKFGFLTEVS
110 120 130 140 150
ESGLKEAVSR LARGDFNLEE HRKLRIKIGG SDEGDALNEV TVITSRPAKM
160 170 180 190 200
IRYRLSIDGF ELETTWADGV LVATPTGSTA YSLSAGGPIV EPQVECSIIT
210 220 230 240 250
PLNPFKLEAR PMVVSMDRRV EIDVDDPERA EVVVDGQEYM NLDGTVSVTR
260 270
SPNVARFIRF GSTYFERLKE KFLRWD
Length:276
Mass (Da):30,665
Last modified:June 1, 2002 - v1
Checksum:iCD0A6C3606133CE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01956.1

Genome annotation databases

EnsemblBacteriaiAAM01956; AAM01956; MK0742
KEGGimka:MK0742
PATRICifig|190192.8.peg.782

Entry informationi

Entry nameiNADK_METKA
AccessioniPrimary (citable) accession number: Q8TXD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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