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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:MK0757
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197181 – 571Glutamate--tRNA ligaseAdd BLAST571

Proteomic databases

PRIDEiQ8TXB7

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0757

Structurei

3D structure databases

ProteinModelPortaliQ8TXB7
SMRiQ8TXB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi105 – 115"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302 Archaea
COG0008 LUCA
HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP
OrthoDBiPOG093Z013J

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TXB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKELRDLV RRYALENAAR YGGRANPNAV MKKIMKEHEE LRPRAKEVLK
60 70 80 90 100
TVREVVREVN KMSGEEIRRE LEELGGPRED VARDKEGLKP LPGAEPGNVR
110 120 130 140 150
LRFAPNPSGP LHIGHARAAV LNDEYARRYD GTLVLRIEDT DPRRVDPEAY
160 170 180 190 200
DMIEEDLEWL GVNIDERYVQ SNRIELYYMV CEELLEREGA YVCTCDPDEF
210 220 230 240 250
RRLRDVGRAC PCRSRDKEEN LELWEEMLDG TFSEGEAVVR VKTEVDHPDP
260 270 280 290 300
AVREWIAFRI VEEEHPMTGS RYLVWPTMNF AVAVDDHLMN ITHVLRGKDH
310 320 330 340 350
ESNTRRQKYV FEHLGWDTPE YVHYGILKVE GAVLSTSEIR RGIDSGEYTG
360 370 380 390 400
WDDVRVATLR ALRRRGIKPE AIRETILEIG LTDVDATFSW EHLYARNRKM
410 420 430 440 450
IDPESHRYFF VRDPVELRIE GMKESVLARL PLHPDRDEGE RVLILHPENG
460 470 480 490 500
VARALLDGED AEDLWEGDVV RLMNAVNVEI EEVGDGWLRG RYHSDDYRIA
510 520 530 540 550
KEEGAQIVHW VPPDQAVRCE VVRPDGSVES GYAEINVERE QAGSTVQFER
560 570
LYFVRLEEVS SGGVRAVYAH D
Length:571
Mass (Da):65,975
Last modified:June 1, 2002 - v1
Checksum:i179C1C850B9B4308
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01971.1

Genome annotation databases

EnsemblBacteriaiAAM01971; AAM01971; MK0757
KEGGimka:MK0757
PATRICifig|190192.8.peg.797

Entry informationi

Entry nameiSYE_METKA
AccessioniPrimary (citable) accession number: Q8TXB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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