Q8TXB6 (SYR_METKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	MK0758

Organism

Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)

Taxonomic identifier

190192 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	592 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 592	592	Arginine--tRNA ligase HAMAP MF_00123		PRO_0000151647
Regions
	Motif	139 – 149	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q8TXB6 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: E395C45BCD470C52	FASTA	592	67,767
	10 20 30 40 50 60 MAEETTPRDP FSVTIRTIRT SIRDAISSVY EVDELIEVPI DENPPVEGAD LATPVALSLA 70 80 90 100 110 120 KELDENPREL AETIVEESDL DDVVFVEKAW VEGPGFINLK LDRSQYAALT LRSIFYYGEE 130 140 150 160 170 180 YGSLDLGMGR PVILEHTSAN PNGPLHIGHG RNAVIGDILA RCMVFTNYGV EVQYYVNDMG 190 200 210 220 230 240 KQIAMLAWKY IKEGRPEVPE GEKPDEFFGK LYTEAAREIE EDPELEEVVE RFLRSYERYL 250 260 270 280 290 300 VEEESRAERI ADAFQTVVEE CLRGHIQTLE RLRVAHDRFV YESEFARDAL EIVEKLLDMG 310 320 330 340 350 360 VAEEREDGAV VVDLEDYGID KELVLTRSDG TTLYTTRDIA YHLWKLGRAT FVVDVLGADH 370 380 390 400 410 420 KLAVEQLRAV LDMLEENPDR IDVVFYEFIH LPEGSMSTRK GRYVTLDEFL EEAKKRALEK 430 440 450 460 470 480 MKAAGVAEEL SDEEREKIAE EIAIGAVRFA IARVSPNKPI EFDWDEALDF RRGGPFIQYA 490 500 510 520 530 540 YARAKSILRK ADEEVNRFDA AYLNDDHSFE LILKMSKFPR HVAQCVRKRR PDILAEYAYD 550 560 570 580 590 LAKTFHTFYE EVPVLHVEDD EVREARLKLV EAFTIVAENL MNLLGIPTLE RM

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009439 Genomic DNA. Translation: AAM01972.1.
RefSeq	NP_614042.1. NC_003551.1.
3D structure databases
ProteinModelPortal	Q8TXB6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1476859.
GenomeReviews	Gene locus MK0758 in contig AE009439_GR.
KEGG	mka:MK0758.
NMPDR	fig|190192.1.peg.755.
Phylogenomic databases
HOGENOM	HBG695395.
OMA	NPNGPLH.
PhylomeDB	Q8TXB6.
Enzyme and pathway databases
BioCyc	MKAN190192:MK0758-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_METKA

Accession

Primary (citable) accession number: Q8TXB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program