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Protein

Dihydroneopterin aldolase

Gene

mptD

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).UniRule annotation

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei16 – 161SubstrateUniRule annotation
Binding sitei111 – 1111Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

UniPathwayiUPA00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolaseUniRule annotation (EC:4.1.2.25UniRule annotation)
Short name:
DHNAUniRule annotation
Alternative name(s):
7,8-dihydroneopterin aldolaseUniRule annotation
Gene namesi
Name:mptDUniRule annotation
Ordered Locus Names:MK0786
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 121121Dihydroneopterin aldolasePRO_0000420353Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi190192.MK0786.

Structurei

Secondary structure

1
121
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2820Combined sources
Helixi35 – 373Combined sources
Helixi38 – 4912Combined sources
Beta strandi55 – 628Combined sources
Helixi66 – 694Combined sources
Turni80 – 823Combined sources
Beta strandi83 – 919Combined sources
Beta strandi94 – 10310Combined sources
Turni104 – 1074Combined sources
Beta strandi108 – 11811Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IECX-ray2.33A/B/C/D2-121[»]
ProteinModelPortaliQ8TX89.
SMRiQ8TX89. Positions 3-119.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TX89.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal dihydroneopterin aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04705. Archaea.
COG2098. LUCA.
HOGENOMiHOG000229383.
KOiK09739.
OMAiMKNQPCV.

Family and domain databases

Gene3Di3.30.1300.20. 1 hit.
HAMAPiMF_02130. DHNA_arch.
InterProiIPR027508. DHN_aldolase_MptD.
IPR007181. MtpD_C.
IPR007179. MtpD_N.
[Graphical view]
PfamiPF04038. DHNA. 1 hit.
[Graphical view]
ProDomiPD027636. DUF372. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF143560. SSF143560. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TX89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYFKRLSDR ERAIFEAGIT LGAIYHQFCG TPVSPGTAEE VAKCIERAAL
60 70 80 90 100
LQPCVIDARV EVDVSSEDTD NYGGYTEVSG RNLRVTIVTR CGEWEAVGKL
110 120
EFIEELNYPL MWVEEIRRVE Q
Length:121
Mass (Da):13,735
Last modified:June 1, 2002 - v1
Checksum:i944CED707FAC7743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02000.1.

Genome annotation databases

EnsemblBacteriaiAAM02000; AAM02000; MK0786.
KEGGimka:MK0786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02000.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IECX-ray2.33A/B/C/D2-121[»]
ProteinModelPortaliQ8TX89.
SMRiQ8TX89. Positions 3-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK0786.

Protocols and materials databases

DNASUi1476887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM02000; AAM02000; MK0786.
KEGGimka:MK0786.

Phylogenomic databases

eggNOGiarCOG04705. Archaea.
COG2098. LUCA.
HOGENOMiHOG000229383.
KOiK09739.
OMAiMKNQPCV.

Enzyme and pathway databases

UniPathwayiUPA00065.

Miscellaneous databases

EvolutionaryTraceiQ8TX89.

Family and domain databases

Gene3Di3.30.1300.20. 1 hit.
HAMAPiMF_02130. DHNA_arch.
InterProiIPR027508. DHN_aldolase_MptD.
IPR007181. MtpD_C.
IPR007179. MtpD_N.
[Graphical view]
PfamiPF04038. DHNA. 1 hit.
[Graphical view]
ProDomiPD027636. DUF372. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF143560. SSF143560. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.
  2. "Crystal Structure of uncharacterized conserved archaeal protein from Methanopyrus kandleri."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) OF 2-121, SUBUNIT.

Entry informationi

Entry nameiMPTD_METKA
AccessioniPrimary (citable) accession number: Q8TX89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.