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Protein

Dihydroneopterin aldolase

Gene

mptD

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).UniRule annotation

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16SubstrateUniRule annotation1
Binding sitei111Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

UniPathwayiUPA00065

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolaseUniRule annotation (EC:4.1.2.25UniRule annotation)
Short name:
DHNAUniRule annotation
Alternative name(s):
7,8-dihydroneopterin aldolaseUniRule annotation
Gene namesi
Name:mptDUniRule annotation
Ordered Locus Names:MK0786
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004203531 – 121Dihydroneopterin aldolaseAdd BLAST121

Interactioni

Subunit structurei

Homotetramer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi190192.MK0786

Structurei

Secondary structure

1121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 28Combined sources20
Helixi35 – 37Combined sources3
Helixi38 – 49Combined sources12
Beta strandi55 – 62Combined sources8
Helixi66 – 69Combined sources4
Turni80 – 82Combined sources3
Beta strandi83 – 91Combined sources9
Beta strandi94 – 103Combined sources10
Turni104 – 107Combined sources4
Beta strandi108 – 118Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IECX-ray2.33A/B/C/D2-121[»]
ProteinModelPortaliQ8TX89
SMRiQ8TX89
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TX89

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal dihydroneopterin aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04705 Archaea
COG2098 LUCA
HOGENOMiHOG000229383
KOiK09739
OMAiHQFVGTP
OrthoDBiPOG093Z0ISO

Family and domain databases

Gene3Di3.30.1300.20, 1 hit
HAMAPiMF_02130 DHNA_arch, 1 hit
InterProiView protein in InterPro
IPR027508 DHN_aldolase_MptD
IPR036839 MptD_sf
IPR007181 MtpD_C
IPR007179 MtpD_N
PfamiView protein in Pfam
PF04038 DHNA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD027636 DUF372, 1 hit
SUPFAMiSSF143560 SSF143560, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TX89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYFKRLSDR ERAIFEAGIT LGAIYHQFCG TPVSPGTAEE VAKCIERAAL
60 70 80 90 100
LQPCVIDARV EVDVSSEDTD NYGGYTEVSG RNLRVTIVTR CGEWEAVGKL
110 120
EFIEELNYPL MWVEEIRRVE Q
Length:121
Mass (Da):13,735
Last modified:June 1, 2002 - v1
Checksum:i944CED707FAC7743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM02000.1

Genome annotation databases

EnsemblBacteriaiAAM02000; AAM02000; MK0786
KEGGimka:MK0786
PATRICifig|190192.8.peg.828

Entry informationi

Entry nameiMPTD_METKA
AccessioniPrimary (citable) accession number: Q8TX89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health