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Protein

Nucleoside-triphosphatase THEP1

Gene

MK0827

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.UniRule annotation

Catalytic activityi

NTP + H2O = NDP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi99 – 106ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside-triphosphatase THEP1UniRule annotation (EC:3.6.1.15UniRule annotation)
Short name:
NTPase THEP1UniRule annotation
Alternative name(s):
Nucleoside triphosphate phosphohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:MK0827
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001466971 – 180Nucleoside-triphosphatase THEP1Add BLAST180

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0827.

Structurei

3D structure databases

ProteinModelPortaliQ8TX49.
SMRiQ8TX49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THEP1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01034. Archaea.
COG1618. LUCA.
HOGENOMiHOG000006446.
KOiK06928.
OMAiCGFITEE.
OrthoDBiPOG093Z0D4B.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00796. NTPase_1. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR004948. Nuc-triphosphatase_THEP1.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF03266. NTPase_1. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TX49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHNVVLTGR PGIGKTTVCL KVRNVLEEEG YTVGGIYCPE IREGGRRIGF
60 70 80 90 100
EIVDLTEGDR YLLAREGASG PRVGRYGVFV DNLERAAESI ERAVKRTDVV
110 120 130 140 150
IVDEVGPMEL KSNAFVDAVR RAADAHTPAI FVVHERSRHP VVVDLREERP
160 170 180
DVVRFRVTLS NRDELSDRIL EHVLEWLEER
Length:180
Mass (Da):20,326
Last modified:June 1, 2002 - v1
Checksum:iE41855768894B701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02040.1.

Genome annotation databases

EnsemblBacteriaiAAM02040; AAM02040; MK0827.
KEGGimka:MK0827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02040.1.

3D structure databases

ProteinModelPortaliQ8TX49.
SMRiQ8TX49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK0827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM02040; AAM02040; MK0827.
KEGGimka:MK0827.

Phylogenomic databases

eggNOGiarCOG01034. Archaea.
COG1618. LUCA.
HOGENOMiHOG000006446.
KOiK06928.
OMAiCGFITEE.
OrthoDBiPOG093Z0D4B.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00796. NTPase_1. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR004948. Nuc-triphosphatase_THEP1.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF03266. NTPase_1. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTPTH_METKA
AccessioniPrimary (citable) accession number: Q8TX49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2002
Last modified: February 15, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.