Q8TWV0 (Q8TWV0_METKA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Coenzyme F420-reducing hydrogenase, alpha subunit EMBL AAM02144.1

Gene names

Ordered Locus Names:

MK0931

Organism

Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)

Taxonomic identifier

190192 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. RuleBase RU003896

Ontologies

Keywords
Coding sequence diversity	Selenocysteine EMBL AAM02144.1
Ligand	Metal-binding RuleBase RU003896 Nickel RuleBase RU003896 Selenium EMBL AAM02144.1
Molecular function	Oxidoreductase RuleBase RU003896
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	coenzyme F420 hydrogenase activity Inferred from electronic annotation. Source: InterPro ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro iron-sulfur cluster binding Inferred from electronic annotation. Source: InterPro nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Non-standard residue	388	1	Selenocysteine EMBL AAM02144.1

Sequences

	Sequence		Length	Mass (Da)
	Q8TWV0 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: F780CFE8269C821D	FASTA	416	46,868
	10 20 30 40 50 60 MAEGAVEIQP TTRHEGHAKL VLYVDDEGYV ERAFYLNTSA VRGFEALAKG RPAEFVQVAV 70 80 90 100 110 120 MRICGICQAT HGTASAEAFE RAMGIEPPKD GKLLRELCAL GNRIQSHVLH QLLVLDDFVE 130 140 150 160 170 180 DESEKVEAVK RIQQIRRIGQ YVVDVVGGEG IHPPNIRIGG MAENISEAAR RKLYRRLREA 190 200 210 220 230 240 RELMMEQHEF MVNIVERFGD ENDLDIDEFG RHDQPFLATH PTYGDPDRLD MDRVVELLPI 250 260 270 280 290 300 EYYGEEHKEV AYQHRGQIPL YDGVPVEVGP RARYILFDGV DPRGVLYIHV LRSQETLAAI 310 320 330 340 350 360 DRAMTILDEL NTSGKTLAEW EPKAGVGIGV HEAPRGTNVH IAKVNEKGIV EDYRIIAAST 370 380 390 400 410 WNFPVVEKAI EGENEEYAEV IMRCYDIUAS CAAHVVKEVR DADSREKIRE SVVKLA

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009439 Genomic DNA. Translation: AAM02144.1.
RefSeq	NP_614214.1. NC_003551.1.
3D structure databases
ProteinModelPortal	Q8TWV0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1477032.
GenomeReviews	Gene locus MK0931 in contig AE009439_GR.
KEGG	mka:MK0931.
Phylogenomic databases
HOGENOM	HBG287963.
OMA	DIXASCA.
Family and domain databases
InterPro	IPR017682. Coenz_F420_hydrogenase_asu. IPR001501. Ni-dep_hyd_lsu. IPR018194. Ni-dep_hyd_lsu_Ni_BS. [Graphical view]
KO	K00440.
Pfam	PF00374. NiFeSe_Hases. 2 hits. [Graphical view]
TIGRFAMs	TIGR03295. FrhA. 1 hit.
PROSITE	PS00507. NI_HGENASE_L_1. 1 hit. PS00508. NI_HGENASE_L_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8TWV0_METKA

Accession

Primary (citable) accession number: Q8TWV0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	February 26, 2008
Last modified:	November 16, 2011
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)