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Protein

Putative adenylate kinase

Gene

MK1060

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15ATPUniRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMKAN190192:G139I-1085-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenylate kinaseUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AKUniRule annotation
Alternative name(s):
ATP-AMP transphosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:MK1060
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539071 – 190Putative adenylate kinaseAdd BLAST190

Proteomic databases

PRIDEiQ8TWH4

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1060

Structurei

3D structure databases

ProteinModelPortaliQ8TWH4
SMRiQ8TWH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 52NMPbindUniRule annotationAdd BLAST24
Regioni102 – 112LIDUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01038 Archaea
COG1936 LUCA
HOGENOMiHOG000224471
KOiK18532
OMAiDNVQCEI
OrthoDBiPOG093Z0F8E

Family and domain databases

HAMAPiMF_00039 Adenylate_kinase_AK6, 1 hit
InterProiView protein in InterPro
IPR020618 Adenyl_kinase_AK6
IPR027417 P-loop_NTPase
PANTHERiPTHR12595:SF0 PTHR12595:SF0, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TWH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAITGTPG VGKTTVCEAL RDLGFDVVHL NKVAREMDAI LEEDEQRQAK
60 70 80 90 100
VVDLHALRRY VEEWEPESDP AFVESHYAHL MPTDLVIVLR LHPSELERRL
110 120 130 140 150
KEKGYPPEKI AENLEAEFVG VCYGEAVEVR SEGCFIRPPE DVIQVNVTGL
160 170 180 190
SRAEAADRVL EAVNHRRGDD VDWLSDEEAQ RTVERYLKYR
Length:190
Mass (Da):21,695
Last modified:June 1, 2002 - v1
Checksum:i942DD7EB07F64B2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM02273.1

Genome annotation databases

EnsemblBacteriaiAAM02273; AAM02273; MK1060
KEGGimka:MK1060
PATRICifig|190192.8.peg.1114

Entry informationi

Entry nameiKAD6_METKA
AccessioniPrimary (citable) accession number: Q8TWH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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