Q8TWH4 (KAD6_METKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative adenylate kinase
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Ordered Locus Names:

MK1060

Organism

Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)

Taxonomic identifier

190192 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00039
Sequence similarities	Belongs to the adenylate kinase family. AK6 subfamily.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC dephospho-CoA kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Putative adenylate kinase HAMAP MF_00039		PRO_0000153907
Regions
	Nucleotide binding	7 – 14	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8TWH4 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 942DD7EB07F64B2F	FASTA	190	21,695
	10 20 30 40 50 60 MKIAITGTPG VGKTTVCEAL RDLGFDVVHL NKVAREMDAI LEEDEQRQAK VVDLHALRRY 70 80 90 100 110 120 VEEWEPESDP AFVESHYAHL MPTDLVIVLR LHPSELERRL KEKGYPPEKI AENLEAEFVG 130 140 150 160 170 180 VCYGEAVEVR SEGCFIRPPE DVIQVNVTGL SRAEAADRVL EAVNHRRGDD VDWLSDEEAQ 190 RTVERYLKYR

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009439 Genomic DNA. Translation: AAM02273.1.
RefSeq	NP_614343.1. NC_003551.1.
3D structure databases
ProteinModelPortal	Q8TWH4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1477161.
GenomeReviews	Gene locus MK1060 in contig AE009439_GR.
KEGG	mka:MK1060.
NMPDR	fig|190192.1.peg.1056.
Phylogenomic databases
HOGENOM	HBG646389.
OMA	FISGTPC.
PhylomeDB	Q8TWH4.
Enzyme and pathway databases
BioCyc	MKAN190192:MK1060-MONOMER.
Family and domain databases
HAMAP	MF_00039. Put_adenyl_kinase. [Tree]
InterPro	IPR020618. Adenylate_kinase_putative. IPR001977. Depp_CoAkinase. [Graphical view]
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD6_METKA

Accession

Primary (citable) accession number: Q8TWH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program