Reviewed, UniProtKB/Swiss-Prot Q8TWH4 (KAD6_METKA)

Names and origin

Protein names

Recommended name:
    Putative adenylate kinase
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase

Gene names

Ordered Locus Names:

MK1060

Organism

Methanopyrus kandleri [Complete proteome] [HAMAP]

Taxonomic identifier

2320 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00039
Sequence similarities	Belongs to the adenylate kinase family. AK6 subfamily.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Putative adenylate kinase HAMAP MF_00039		PRO_0000153907
Regions
	Nucleotide binding	7 – 14	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8TWH4-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 942DD7EB07F64B2F	FASTA	190	21,695
	10 20 30 40 50 60 MKIAITGTPG VGKTTVCEAL RDLGFDVVHL NKVAREMDAI LEEDEQRQAK VVDLHALRRY 70 80 90 100 110 120 VEEWEPESDP AFVESHYAHL MPTDLVIVLR LHPSELERRL KEKGYPPEKI AENLEAEFVG 130 140 150 160 170 180 VCYGEAVEVR SEGCFIRPPE DVIQVNVTGL SRAEAADRVL EAVNHRRGDD VDWLSDEEAQ 190 RTVERYLKYR

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010395 Genomic DNA. Translation: AAM02273.1.
RefSeq	NP_614343.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1477161.
GenomeReviews	Gene locus MK1060 in contig AE009439_GR.
KEGG	mka:MK1060.
NMPDR	fig|190192.1.peg.1056.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8TWH4.
OMA	Q8TWH4. QSYIIDE.
Enzyme and pathway databases
BioCyc	MKAN190192:MK1060-MON.
BRENDA	2.7.4.3. 7577.
Family and domain databases
HAMAP	MF_00039. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD6_METKA

Accession

Primary (citable) accession number: Q8TWH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)