SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8TWG5

- MDH_METKA

UniProt

Q8TWG5 - MDH_METKA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Malate dehydrogenase

Gene
mdh, MK1069
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Substrate By similarity
Binding sitei91 – 911Substrate By similarity
Binding sitei98 – 981NAD By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei154 – 1541Substrate By similarity
Active sitei178 – 1781Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 147NAD By similarity
Nucleotide bindingi121 – 1233NAD By similarity

GO - Molecular functioni

  1. L-lactate dehydrogenase activity Source: InterPro
  2. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:MK1069
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Malate dehydrogenaseUniRule annotationPRO_0000113486Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1069.

Structurei

3D structure databases

ProteinModelPortaliQ8TWG5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213793.
KOiK00024.
OMAiITIGCER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TWG5-1 [UniParc]FASTAAdd to Basket

« Hide

MSKVAVIGAT GRVGSTAAAR LALLDCVNEV TLIARPKSVD KLRGLRRDIL    50
DSLAAAQKDA EITIGCERDD YVDADVIVMT AGIPRKPGQT RLDLTKDNAA 100
IIKKYLEGVA EENPEAIVLV VTNPVDVLTY VALKVSGLPK NRVIGLGTHL 150
DSMRFKVLIA KHFNVHMSEV HTRIIGEHGD TMVPVISSTS VGGIPVTRMP 200
GWEDFDVEEA VREVKEAGQR IIETWGGSQF GPAQAITNLV RTILQDERRV 250
LTVSAYLDGE IDGIRDVCIG VPARLGREGV LEIVPIELEE DEMRAFRRSV 300
KVVKEATREA MEAISER 317
Length:317
Mass (Da):34,609
Last modified:June 1, 2002 - v1
Checksum:iD2AC04B7C0B6C26E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM02282.1.
RefSeqiNP_614352.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM02282; AAM02282; MK1069.
GeneIDi1477170.
KEGGimka:MK1069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM02282.1 .
RefSeqi NP_614352.1. NC_003551.1.

3D structure databases

ProteinModelPortali Q8TWG5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190192.MK1069.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM02282 ; AAM02282 ; MK1069 .
GeneIDi 1477170.
KEGGi mka:MK1069.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213793.
KOi K00024.
OMAi ITIGCER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Entry informationi

Entry nameiMDH_METKA
AccessioniPrimary (citable) accession number: Q8TWG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi