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Q8TW25 (UPPP_METKA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27
Alternative name(s):
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:MK1212
OrganismMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) [Reference proteome] [HAMAP]
Taxonomic identifier190192 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus ›

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Sequence similarities

Belongs to the UppP family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdephosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionundecaprenyl-diphosphatase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151250

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8TW25 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: F87F59EACB982AF3

FASTA26928,622
        10         20         30         40         50         60 
MREIELWTAV LAGVVQGITE WLPISSEGQA TMTMMKVLGI PPSTAMDLAL WLHAGTLLAV 

        70         80         90        100        110        120 
LLRFGVPYWL TVRDLLMGGP WRRLGLFAIV ATVCTAVVGL PVYKVLKGIF SAATGDAVQM 

       130        140        150        160        170        180 
AIGGALIVTG LLLRISPEGL RDRREVNVVD AVIVGLGQGF SVIPGISRSG TTMALLLWRR 

       190        200        210        220        230        240 
FDGGEAVWLS FYLAGPAMLG ATALELKEGL SAATKMGTSW MVTAIGVSFV VSLICMEVLL 

       250        260 
RVARRLDFSK VCLLLGGIAL LVPLAAKML

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References

[1]"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens."
Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A.
Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE009439 Genomic DNA. Translation: AAM02425.1.
RefSeqNP_614495.1. NC_003551.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING190192.MK1212.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM02425; AAM02425; MK1212.
GeneID1477807.
KEGGmka:MK1212.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAFKAWIAS.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase. Divergent sequence.
InterProIPR003824. Bacitracin-R_BacA.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_METKA
AccessionPrimary (citable) accession number: Q8TW25
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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