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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MK1364
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521321 – 943Leucine--tRNA ligaseAdd BLAST943

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1364

Structurei

3D structure databases

ProteinModelPortaliQ8TVM4
SMRiQ8TVM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionAdd BLAST11
Motifi623 – 627"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TVM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERPEERQW KEWEEAGLFE ADPDDRESVY ITVAYPYPSG SMHVGHARTY
60 70 80 90 100
LVPDIYARFK RMQGYNVLFP MAFHVTGTPV VGIAERIKEG DEDTIRLYRD
110 120 130 140 150
LYGVPEEELE KFTEPEAIVE YFAREYEENM KRMGYSIDWR RKFTTVDPEY
160 170 180 190 200
RSFITWQYLR LREKGLVDKG EHPVRYCPHC ENPVGDHDLL EGEDATIEEL
210 220 230 240 250
TLVKFPVEGD DLILVAATFR PETLYGATNV WVKPDEEYLV VEVDGERWVV
260 270 280 290 300
SEEAYRNLRH QKDGVEKVDT VRGEELIGES VVNPVTGEAL PVLPAEFIDP
310 320 330 340 350
KFGTGVVYSV PAHAPADAAA LEDLKKDPSV LEEYGVDPSV VEELEPVQVI
360 370 380 390 400
EVEGYGEFPA YDALEEHGIE SQTDPELEKA TQEVYRAELH KGVMVVDEFE
410 420 430 440 450
GTPVREAREE IKSRLIESGD ADVMYDFSEK PVICRCGTEC VVRILKDQWF
460 470 480 490 500
LRYSDGEWKE RAEELLGRME IVPEEVRANF EDTIEWLDDW ACARRVGLGT
510 520 530 540 550
PLPWDPDWIV EPLSDSTVYM AYYTIAHRLK GKGELPPEVF DYVFLGEGDP
560 570 580 590 600
EEIAEKAGLD VEELEAMREE FEYWYPLNWR LSAKDLVTNH LTFFIFHHAA
610 620 630 640 650
LFPEDKWPKG IVVFGMGLLE GQKMSSSKGN VVLLSEALDE YGPDVVRLFL
660 670 680 690 700
ATSAEPWQDF DWRDEYVRGV QRHLERFETL IRDHADESVE DKDAVDRWFL
710 720 730 740 750
HEFREVVEET TEALEGFQIR RAYNRAFYGV MKLLREYEAM KGHVKILGEI
760 770 780 790 800
AEDWLKLLHP VIPFATDRLW REVLGEDSFL LEEEWPDPSE YPEEPELSVA
810 820 830 840 850
KEVLDRLIED VRDVEKVIGA EPGYTLHVYL APEWQWRALE LILKDKEFGE
860 870 880 890 900
VMSELMKDEG LREKGDEVAK IVQELTKEDL PEDVDVDALR EALTEFLEAA
910 920 930 940
GRALTDKTGA SEVVIHTDPE EAPGPEDRKA GARPLRPGIW LEE
Length:943
Mass (Da):108,672
Last modified:June 1, 2002 - v1
Checksum:i9B5D4567D2588094
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM02577.1

Genome annotation databases

EnsemblBacteriaiAAM02577; AAM02577; MK1364
KEGGimka:MK1364
PATRICifig|190192.8.peg.1516

Similar proteinsi

Entry informationi

Entry nameiSYL_METKA
AccessioniPrimary (citable) accession number: Q8TVM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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