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Q8TVM4

- SYL_METKA

UniProt

Q8TVM4 - SYL_METKA

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Protein
Leucine--tRNA ligase
Gene
leuS, MK1364
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:MK1364
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943Leucine--tRNA ligaseUniRule annotation
PRO_0000152132Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1364.

Structurei

3D structure databases

ProteinModelPortaliQ8TVM4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionUniRule annotation
Add
BLAST
Motifi623 – 6275"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TVM4-1 [UniParc]FASTAAdd to Basket

« Hide

MAERPEERQW KEWEEAGLFE ADPDDRESVY ITVAYPYPSG SMHVGHARTY    50
LVPDIYARFK RMQGYNVLFP MAFHVTGTPV VGIAERIKEG DEDTIRLYRD 100
LYGVPEEELE KFTEPEAIVE YFAREYEENM KRMGYSIDWR RKFTTVDPEY 150
RSFITWQYLR LREKGLVDKG EHPVRYCPHC ENPVGDHDLL EGEDATIEEL 200
TLVKFPVEGD DLILVAATFR PETLYGATNV WVKPDEEYLV VEVDGERWVV 250
SEEAYRNLRH QKDGVEKVDT VRGEELIGES VVNPVTGEAL PVLPAEFIDP 300
KFGTGVVYSV PAHAPADAAA LEDLKKDPSV LEEYGVDPSV VEELEPVQVI 350
EVEGYGEFPA YDALEEHGIE SQTDPELEKA TQEVYRAELH KGVMVVDEFE 400
GTPVREAREE IKSRLIESGD ADVMYDFSEK PVICRCGTEC VVRILKDQWF 450
LRYSDGEWKE RAEELLGRME IVPEEVRANF EDTIEWLDDW ACARRVGLGT 500
PLPWDPDWIV EPLSDSTVYM AYYTIAHRLK GKGELPPEVF DYVFLGEGDP 550
EEIAEKAGLD VEELEAMREE FEYWYPLNWR LSAKDLVTNH LTFFIFHHAA 600
LFPEDKWPKG IVVFGMGLLE GQKMSSSKGN VVLLSEALDE YGPDVVRLFL 650
ATSAEPWQDF DWRDEYVRGV QRHLERFETL IRDHADESVE DKDAVDRWFL 700
HEFREVVEET TEALEGFQIR RAYNRAFYGV MKLLREYEAM KGHVKILGEI 750
AEDWLKLLHP VIPFATDRLW REVLGEDSFL LEEEWPDPSE YPEEPELSVA 800
KEVLDRLIED VRDVEKVIGA EPGYTLHVYL APEWQWRALE LILKDKEFGE 850
VMSELMKDEG LREKGDEVAK IVQELTKEDL PEDVDVDALR EALTEFLEAA 900
GRALTDKTGA SEVVIHTDPE EAPGPEDRKA GARPLRPGIW LEE 943
Length:943
Mass (Da):108,672
Last modified:June 1, 2002 - v1
Checksum:i9B5D4567D2588094
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM02577.1.
RefSeqiNP_614647.1. NC_003551.1.
WP_011019732.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM02577; AAM02577; MK1364.
GeneIDi1477959.
KEGGimka:MK1364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009439 Genomic DNA. Translation: AAM02577.1 .
RefSeqi NP_614647.1. NC_003551.1.
WP_011019732.1. NC_003551.1.

3D structure databases

ProteinModelPortali Q8TVM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190192.MK1364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM02577 ; AAM02577 ; MK1364 .
GeneIDi 1477959.
KEGGi mka:MK1364.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Entry informationi

Entry nameiSYL_METKA
AccessioniPrimary (citable) accession number: Q8TVM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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