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Q8TVM4

- SYL_METKA

UniProt

Q8TVM4 - SYL_METKA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MK1364
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
ProteomesiUP000001826: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943Leucine--tRNA ligasePRO_0000152132Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1364.

Structurei

3D structure databases

ProteinModelPortaliQ8TVM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi623 – 6275"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TVM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAERPEERQW KEWEEAGLFE ADPDDRESVY ITVAYPYPSG SMHVGHARTY
60 70 80 90 100
LVPDIYARFK RMQGYNVLFP MAFHVTGTPV VGIAERIKEG DEDTIRLYRD
110 120 130 140 150
LYGVPEEELE KFTEPEAIVE YFAREYEENM KRMGYSIDWR RKFTTVDPEY
160 170 180 190 200
RSFITWQYLR LREKGLVDKG EHPVRYCPHC ENPVGDHDLL EGEDATIEEL
210 220 230 240 250
TLVKFPVEGD DLILVAATFR PETLYGATNV WVKPDEEYLV VEVDGERWVV
260 270 280 290 300
SEEAYRNLRH QKDGVEKVDT VRGEELIGES VVNPVTGEAL PVLPAEFIDP
310 320 330 340 350
KFGTGVVYSV PAHAPADAAA LEDLKKDPSV LEEYGVDPSV VEELEPVQVI
360 370 380 390 400
EVEGYGEFPA YDALEEHGIE SQTDPELEKA TQEVYRAELH KGVMVVDEFE
410 420 430 440 450
GTPVREAREE IKSRLIESGD ADVMYDFSEK PVICRCGTEC VVRILKDQWF
460 470 480 490 500
LRYSDGEWKE RAEELLGRME IVPEEVRANF EDTIEWLDDW ACARRVGLGT
510 520 530 540 550
PLPWDPDWIV EPLSDSTVYM AYYTIAHRLK GKGELPPEVF DYVFLGEGDP
560 570 580 590 600
EEIAEKAGLD VEELEAMREE FEYWYPLNWR LSAKDLVTNH LTFFIFHHAA
610 620 630 640 650
LFPEDKWPKG IVVFGMGLLE GQKMSSSKGN VVLLSEALDE YGPDVVRLFL
660 670 680 690 700
ATSAEPWQDF DWRDEYVRGV QRHLERFETL IRDHADESVE DKDAVDRWFL
710 720 730 740 750
HEFREVVEET TEALEGFQIR RAYNRAFYGV MKLLREYEAM KGHVKILGEI
760 770 780 790 800
AEDWLKLLHP VIPFATDRLW REVLGEDSFL LEEEWPDPSE YPEEPELSVA
810 820 830 840 850
KEVLDRLIED VRDVEKVIGA EPGYTLHVYL APEWQWRALE LILKDKEFGE
860 870 880 890 900
VMSELMKDEG LREKGDEVAK IVQELTKEDL PEDVDVDALR EALTEFLEAA
910 920 930 940
GRALTDKTGA SEVVIHTDPE EAPGPEDRKA GARPLRPGIW LEE
Length:943
Mass (Da):108,672
Last modified:June 1, 2002 - v1
Checksum:i9B5D4567D2588094
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02577.1.
RefSeqiNP_614647.1. NC_003551.1.
WP_011019732.1. NC_003551.1.

Genome annotation databases

EnsemblBacteriaiAAM02577; AAM02577; MK1364.
GeneIDi1477959.
KEGGimka:MK1364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02577.1 .
RefSeqi NP_614647.1. NC_003551.1.
WP_011019732.1. NC_003551.1.

3D structure databases

ProteinModelPortali Q8TVM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190192.MK1364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM02577 ; AAM02577 ; MK1364 .
GeneIDi 1477959.
KEGGi mka:MK1364.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Entry informationi

Entry nameiSYL_METKA
AccessioniPrimary (citable) accession number: Q8TVM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3