Reviewed, UniProtKB/Swiss-Prot Q8TVM0 (SELD_METKA)

Names and origin

Protein names

Recommended name:
    Selenide, water dikinase
    EC=2.7.9.3
Alternative name(s):
    Selenophosphate synthetase
    Selenium donor protein

Gene names

Name:	selD
Ordered Locus Names:	MK1369

Organism

Methanopyrus kandleri [Complete proteome] [HAMAP]

Taxonomic identifier

2320 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanopyri › Methanopyrales › Methanopyraceae › Methanopyrus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP By similarity.
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate. HAMAP MF_00625
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the selenophosphate synthetase 1 family. Class I subfamily.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	ATP-binding Magnesium Nucleotide-binding Selenium
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP selenide, water dikinase activity Inferred from electronic annotation. Source: HAMAP selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Selenide, water dikinase HAMAP MF_00625		PRO_0000127646
Regions
	Nucleotide binding	234 – 240	7	ATP Potential
Sites
	Active site	16	1	Potential
	Site	19	1	Important for catalytic activity By similarity
Amino acid modifications
	Non-standard residue	16	1	Selenocysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8TVM0-1 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: 1472409D983757D8	FASTA	334	35,918
	10 20 30 40 50 60 MSRKKSLVEM ADLHGUACKL PQGDLEDLLK GVELPEEGGR VEVGVGDDAA VIRVDGGYVI 70 80 90 100 110 120 QSVDFFTPIH PDPYTQGRIA ANNSINDVFA MGATEVLSVL VVSGFPRELP EEDAREMLQG 130 140 150 160 170 180 FADQCREVDA LIVGGHTIMN PWPILGGCVT GFAERYVTVG GAEPGDVLYL TKPLGTQPAM 190 200 210 220 230 240 AALRLPEDVR KQFLTDSELE EAVDLAVEVM TEPLKDAAEA ALEVGVHAMT DVTGFGLKGH 250 260 270 280 290 300 AGEMAEASGV RVVIERLPVI PGTTELSRAL GYGLERGESA ETAGGLLVAV PEEHAEDLED 310 320 330 AFERRDVWYR RIGRVEEGSG VEVRGDVEEV EDYP

References

[1]

"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens." Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N., Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A., Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G., Koonin E.V., Kozyavkin S.A. Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002) [PubMed: 11930014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AV19 / DSM 6324 / JCM 9639 / NBRC 100938.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE009439 Genomic DNA. Translation: AAM02582.1.
RefSeq	NP_614652.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1477964.
GenomeReviews	Gene locus MK1369 in contig AE009439_GR.
KEGG	mka:MK1369.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8TVM0.
OMA	AMGISEI.
Enzyme and pathway databases
BRENDA	2.7.9.3. 7577.
Family and domain databases
HAMAP	MF_00625. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004536. SelD. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
TIGRFAMs	TIGR00476. selD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SELD_METKA

Accession

Primary (citable) accession number: Q8TVM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 36 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)