Q8TV34DUT_METKAProbable deoxyuridine 5'-triphosphate nucleotidohydrolasedUTPase3.6.1.23dUTP pyrophosphatasedutMK1566Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)ArchaeaEuryarchaeotaMethanomada groupMethanopyriMethanopyralesMethanopyraceaeMethanopyrusThe complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.dUTP + H2O = diphosphate + dUMP + H(+)Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.HydrolaseNucleotide metabolismReference proteomeMILGEYVLRDLFPDLDEDQYQPAGIDLKLDRVFRLEGRGALLEGDDKRLPEYREVETEGGVFELEPNVPYVLELAPELEIPEDTAVLFLPRSTLLRSGVSVHTALGDPGFRGKIRVLAVNHHAAPYRIAHGERVVQAVFLRAEDAGRYEGDYGR
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