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Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24GTPUniRule annotation8
Nucleotide bindingi81 – 85GTPUniRule annotation5
Nucleotide bindingi135 – 138GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:MK1595
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373021 – 598Probable translation initiation factor IF-2Add BLAST598

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1595.

Structurei

3D structure databases

ProteinModelPortaliQ8TV06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 226tr-type GAdd BLAST219

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 24G1By similarity8
Regioni42 – 46G2By similarity5
Regioni81 – 84G3By similarity4
Regioni135 – 138G4By similarity4
Regioni203 – 205G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
HOGENOMiHOG000105770.
KOiK03243.
OMAiLSQRYMK.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TV06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESNKAIRQ PIISVLGHVD HGKTTLLDKI RGTAVAAKEA GGITQHIGAS
60 70 80 90 100
EIPLEVVKEI CGPLLEQLDV EITIPGLLFI DTPGHEAFTN LRRRGGALAD
110 120 130 140 150
IAILVIDIME GVMPQTEEAL RILRRYRTPF VVAANKVDRV PGWKSHEDTP
160 170 180 190 200
FLESFQKQSP EVQQRLEEKV YELIGQLHQH GFQAERFDRV RDFTRTVAIV
210 220 230 240 250
PTSGVTGEGI PELLMVVTGL AQRFLEEQLK IEVEGPGKAA ILEVKEEPGL
260 270 280 290 300
GHTVDAILYD GIIRTGDTIV IGHPEEPIVT RVRSLLKPKP LDEMRDPSDR
310 320 330 340 350
FRKVDEVTAA AGVKISAPEL EEAVAGAPLR VVGEDEDVEE VVREVQEEVE
360 370 380 390 400
EVTIETDQEG IIIKADTLGT LEAVVGEFKE KDVPIRKADV GDITKKDVIE
410 420 430 440 450
AHAVAEKDPL LGVIVGFNVG VTEEARELAD EYDVDIIIDD VIYELVEKYE
460 470 480 490 500
EMVEKRIERE RRKRLDELVR PGKIKVLPGY IFRQSKPAIV GVQVLAGVIK
510 520 530 540 550
PGYPLMREDG RELGEIKQIQ MHGEPIKEAK KGQEVAISIE GPIVGRHFEE
560 570 580 590
GDILYTDVPS EHAKLMFEEF KDLLTEDELE ALKEIAEIKR KEDPFYGM
Length:598
Mass (Da):66,605
Last modified:June 1, 2002 - v1
Checksum:i080BB46FB486FB27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02808.1.

Genome annotation databases

EnsemblBacteriaiAAM02808; AAM02808; MK1595.
KEGGimka:MK1595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02808.1.

3D structure databases

ProteinModelPortaliQ8TV06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK1595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM02808; AAM02808; MK1595.
KEGGimka:MK1595.

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
HOGENOMiHOG000105770.
KOiK03243.
OMAiLSQRYMK.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2P_METKA
AccessioniPrimary (citable) accession number: Q8TV06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.