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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:MK1597
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Peptidyl-tRNA hydrolasePRO_0000120293Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190192.MK1597.

Structurei

3D structure databases

ProteinModelPortaliQ8TV04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04228. Archaea.
COG1990. LUCA.
HOGENOMiHOG000227349.
KOiK04794.
OMAiQVAHGAV.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
HAMAPiMF_00628. Pept_tRNA_hydro_arch. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TV04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKQVIVVRG DLKLSRGKLA AQVAHASLGA FLRAKESGAP VEEWLREGQK
60 70 80 90 100
KVVLKCKDKE ELLELHELAK RRGLPSFLVR DAGLTELEPG TVTCLGIGPE
110
REEEIDRVTG DLPLLR
Length:116
Mass (Da):12,871
Last modified:June 1, 2002 - v1
Checksum:iD9556F87E16102CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02810.1.

Genome annotation databases

EnsemblBacteriaiAAM02810; AAM02810; MK1597.
KEGGimka:MK1597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA. Translation: AAM02810.1.

3D structure databases

ProteinModelPortaliQ8TV04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190192.MK1597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM02810; AAM02810; MK1597.
KEGGimka:MK1597.

Phylogenomic databases

eggNOGiarCOG04228. Archaea.
COG1990. LUCA.
HOGENOMiHOG000227349.
KOiK04794.
OMAiQVAHGAV.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
HAMAPiMF_00628. Pept_tRNA_hydro_arch. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTH_METKA
AccessioniPrimary (citable) accession number: Q8TV04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.