ID   Q8TUP6_METAC            Unreviewed;       739 AA.
AC   Q8TUP6;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 108.
DE   SubName: Full=Methyl-accepting chemotaxis protein {ECO:0000313|EMBL:AAM03473.1};
GN   Name=mcp-2 {ECO:0000313|EMBL:AAM03473.1};
GN   OrderedLocusNames=MA_0019 {ECO:0000313|EMBL:AAM03473.1};
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM03473.1, ECO:0000313|Proteomes:UP000002487};
RN   [1] {ECO:0000313|EMBL:AAM03473.1, ECO:0000313|Proteomes:UP000002487}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC   {ECO:0000313|Proteomes:UP000002487};
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA   Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA   Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA   de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA   Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA   Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AE010299; AAM03473.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TUP6; -.
DR   STRING; 188937.MA_0019; -.
DR   EnsemblBacteria; AAM03473; AAM03473; MA_0019.
DR   KEGG; mac:MA_0019; -.
DR   HOGENOM; CLU_000445_107_19_2; -.
DR   InParanoid; Q8TUP6; -.
DR   PhylomeDB; Q8TUP6; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd11386; MCP_signal; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR032255; HBM.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM01358; HBM; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS51753; HBM; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002487};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        350..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          87..343
FT                   /note="HBM"
FT                   /evidence="ECO:0000259|PROSITE:PS51753"
FT   DOMAIN          374..422
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          441..677
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   DOMAIN          628..690
FT                   /note="T-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50192"
FT   REGION          681..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   739 AA;  82033 MW;  52BED722910C1DD7 CRC64;
     MGNLNKTFTG ISFTGVISFC PFQQGSPWVV MWLQDRKGRK AKKLEARVKK MYKSTKIGHV
     VIGFALLLIL IFFVGYTGYQ GMTEVEKKSR AIQNMTFIMN NMQDALQAEE SYIIHRDPAY
     KEEVYRYLSL VPTQAAISKE IYIGYLDPVN RDRMDFVLSA SSNFSEAFDR YVEADDEQAA
     VRDKLVADSE TLIANADELS KNQMIQYREE FESGYSNGTL EKKFSNAESS RSIIVLTMKA
     RNEYQNYAMS SDQQYADNFD AYMEDLIELS TDLNGRMERP ENIALGDEIL TSAENFQADF
     EQFKVLEERK TLEEENMRAI ATQVEEVATA ASADQKEELD SLIVNSINQI FLVTFLSILI
     GVLLVFVILD IYRKPIYELL EAADKISEGD LDVDIKGSSR SEIYQLSEAF KAMVENLRSL
     IKEIQEGSLH LATLSEEMSS SSEEVASASR RISETAGEIS NGAEMQSTKI VDITHAMQDM
     THNIQEVADN TQKVSKSTNL VNETVSNIGN VSRDVLSKMD LIRSSVAGTE VVIKELDSKS
     QQINEIITLI TRIADQTNML ALNAAIEAAR AGEHGRGFSV VADEVRKLAE ESGSAAQNIS
     RLIDEIRESI SDTVESIEAS KKNVKNGSIS VSEEVEMVTG IVSTINEITN MIEDVAAATE
     EQSASIEEIT STLEDISSIS EQSAAGTQET AAALEEQSAS MSELASMAND LSLLGEKMKK
     ATEKFRLGDS KEESESSFE
//