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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:MA_0043
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516451 – 567Arginine--tRNA ligaseAdd BLAST567

Interactioni

Protein-protein interaction databases

STRINGi188937.MA0043.

Structurei

3D structure databases

ProteinModelPortaliQ8TUM3.
SMRiQ8TUM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi121 – 131"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00487. Archaea.
COG0018. LUCA.
InParanoidiQ8TUM3.
KOiK01887.
OMAiNKPLHLG.
OrthoDBiPOG093Z013U.
PhylomeDBiQ8TUM3.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TUM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKAQATSI LKEAILKVGF EVEDSELQFE TSSHADLASR VAFRLASIHK
60 70 80 90 100
QNPKELASRI VSAIEIPEGS YIGEVSAAGP YINFLAGRHY MDETVTAVRE
110 120 130 140 150
EKEKFGCGAP KDRILLEHTS ANPNGPLHVG HIRNSIIGDT LARILRRAGY
160 170 180 190 200
DVEVQYYVND MGRQIAVVSW ACERFELDLS RKSDAAIADV YIKANVELDK
210 220 230 240 250
NPDYVKKIDA LMEKVEVGDL QTIERFDKAV SLAIAGIKET LLRLNVVHDK
260 270 280 290 300
FVNESRFLKS GEVHDIVERI KATGRTETDK GALVVDLSDY GFEKTLVIQR
310 320 330 340 350
SNGTSLYTTR DLAYHEWKAG QADRIIDVFG ADHKLISGQL RATLNAIGIK
360 370 380 390 400
EPEVVIFEFV SLPEGSMSTR RGQFISADDL FDRVTEAAFE QVESRRPETS
410 420 430 440 450
TEFKKQVAEM VGIGAVRYDI VRVSPEKSTV FNWKEALDFE KQGAPYIQYS
460 470 480 490 500
HARACSILEK AKDEAAWDPA EEITPSLLVE DSEIDLIKKM AMFDSIIDLG
510 520 530 540 550
ARELKPHVLA IYARELADSF NQFYRFVPVI AAEDEKVRAS RLALVDCARI
560
VLANSLDTLG IGAPESM
Length:567
Mass (Da):63,222
Last modified:June 1, 2002 - v1
Checksum:i04BAC66ABA40921A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM03497.1.

Genome annotation databases

EnsemblBacteriaiAAM03497; AAM03497; MA_0043.
KEGGimac:MA_0043.

Similar proteinsi

Entry informationi

Entry nameiSYR_METAC
AccessioniPrimary (citable) accession number: Q8TUM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families