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Q8TUM3 (SYR_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:MA_0043
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 567567Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151645

Regions

Motif121 – 13111"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q8TUM3 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 04BAC66ABA40921A

FASTA56763,222
        10         20         30         40         50         60 
MELKAQATSI LKEAILKVGF EVEDSELQFE TSSHADLASR VAFRLASIHK QNPKELASRI 

        70         80         90        100        110        120 
VSAIEIPEGS YIGEVSAAGP YINFLAGRHY MDETVTAVRE EKEKFGCGAP KDRILLEHTS 

       130        140        150        160        170        180 
ANPNGPLHVG HIRNSIIGDT LARILRRAGY DVEVQYYVND MGRQIAVVSW ACERFELDLS 

       190        200        210        220        230        240 
RKSDAAIADV YIKANVELDK NPDYVKKIDA LMEKVEVGDL QTIERFDKAV SLAIAGIKET 

       250        260        270        280        290        300 
LLRLNVVHDK FVNESRFLKS GEVHDIVERI KATGRTETDK GALVVDLSDY GFEKTLVIQR 

       310        320        330        340        350        360 
SNGTSLYTTR DLAYHEWKAG QADRIIDVFG ADHKLISGQL RATLNAIGIK EPEVVIFEFV 

       370        380        390        400        410        420 
SLPEGSMSTR RGQFISADDL FDRVTEAAFE QVESRRPETS TEFKKQVAEM VGIGAVRYDI 

       430        440        450        460        470        480 
VRVSPEKSTV FNWKEALDFE KQGAPYIQYS HARACSILEK AKDEAAWDPA EEITPSLLVE 

       490        500        510        520        530        540 
DSEIDLIKKM AMFDSIIDLG ARELKPHVLA IYARELADSF NQFYRFVPVI AAEDEKVRAS 

       550        560 
RLALVDCARI VLANSLDTLG IGAPESM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM03497.1.
RefSeqNP_615017.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TUM3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA0043.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM03497; AAM03497; MA_0043.
GeneID1471935.
KEGGmac:MA0043.

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMANPNGPLH.
PhylomeDBQ8TUM3.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycMACE188937:GI2O-43-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_METAC
AccessionPrimary (citable) accession number: Q8TUM3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries