Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8TUD7 (PUR5_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:MA_0130
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina ›

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the AIR synthase family.

Sequence caution

The sequence AAM03584.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_0000148280

Sequences

Sequence LengthMass (Da)Tools
Q8TUD7 [UniParc].

Last modified November 28, 2003. Version 2.
Checksum: E097F24B54A097CD

FASTA33336,098
        10         20         30         40         50         60 
MSEKHLTYAD SGVDITKEEK TVKTLIDKLS YVRKGIGAPL TGIGHYAGLL DFGEYALAMT 

        70         80         90        100        110        120 
TDGVGSKVLI ANEMKRWNTV GIDCIAMNVN DLLAIGAEPV AFVDYLALEK HEEGFAAQIG 

       130        140        150        160        170        180 
EGLLKGAEIS RMSIVGGETA TLPDIIKGFD LAGTCLGVVK KEDILEGGKV RVGDVLVGIP 

       190        200        210        220        230        240 
STGVHSNGYT LVRKIIEKSG YSYHDPCPYD SSKTIGDELL EPTRIYIEVL DVLKACEVHG 

       250        260        270        280        290        300 
LAHITGSGLL KLRRVTKLGF EFSDPIEPQE IFKFLQKEGE VEDLEMYRTF NMGMGFLMIL 

       310        320        330 
PEKDAAKAAE LTGGKIVGKI VESGIRVKDL IIE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE010299 Genomic DNA. Translation: AAM03584.1. Different initiation.
RefSeqNP_615104.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TUD7.
ModBaseSearch...

Protein-protein interaction databases

STRING188937.MA0130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM03584; AAM03584; MA_0130.
GeneID1472022.
KEGGmac:MA0130.

Phylogenomic databases

eggNOGCOG0150.
KOK01933.
OMAIDMIAMN.
ProtClustDBPRK05385.

Enzyme and pathway databases

BioCycMACE188937:GI2O-196-MONOMER.
UniPathwayUPA00074; UER00129.

Family and domain databases

HAMAPMF_00741_A. AIRS_A.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_METAC
AccessionPrimary (citable) accession number: Q8TUD7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: May 1, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents