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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-189-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MA_0172
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367221 – 437Tryptophan--tRNA ligaseAdd BLAST437

Interactioni

Protein-protein interaction databases

STRINGi188937.MA0172

Structurei

3D structure databases

ProteinModelPortaliQ8TUA1
SMRiQ8TUA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 82"HIGH" region9
Motifi321 – 325"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
InParanoidiQ8TUA1
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X
PhylomeDBiQ8TUA1

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 2 hits
PRINTSiPR01039 TRNASYNTHTRP

Sequencei

Sequence statusi: Complete.

Q8TUA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKLDPWSS SDITDYSKLF EEFGISPFEN VLPEIPSPHM YMRRKVIFGH
60 70 80 90 100
RDYEQIAEAM RTGAPFSVMD GFMPSGKVHL GHKMVMDQIV WHQEMGASAF
110 120 130 140 150
VGIADREAFS VRGFSWQKCR EIGVEEYILS LIALGFKPDG LIYFQSGCGS
160 170 180 190 200
VKDLAFELGA KVNFSELSAI YGFSGETSLS HMLSVATQAA DILQPQLEEF
210 220 230 240 250
GGPKPVVVPV GPDQDPHLRL TRGLAGKMNM FRVEEREDVK TGRKYLSVRG
260 270 280 290 300
KTAQKEALQE LKKRIPGKVK LYEEHIDVLE YPDLAGLEKL VREVTVEFGG
310 320 330 340 350
YAFIPPASTY HRFMSGLQGG KMSSSIPESQ IALTDSPKEG AKKVKRAKTG
360 370 380 390 400
GCVTLEEQKK LGGKPEECSV FELMLFHLIA SDEELLEIKQ ECISGTRMCG
410 420 430
SCKQLAAEKM QEFLKDHQEK RELAREHLDE YRIIYKD
Length:437
Mass (Da):49,067
Last modified:June 1, 2002 - v1
Checksum:i10DF8FBBBFE7A365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM03625.1
RefSeqiWP_011020230.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM03625; AAM03625; MA_0172
GeneIDi1472064
KEGGimac:MA_0172

Similar proteinsi

Entry informationi

Entry nameiSYW_METAC
AccessioniPrimary (citable) accession number: Q8TUA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health