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Q8TUA1

- SYW_METAC

UniProt

Q8TUA1 - SYW_METAC

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMACE188937:GI2O-173-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:MA_0172
    OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
    Taxonomic identifieri188937 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000002487: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Tryptophan--tRNA ligasePRO_0000136722Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi188937.MA0172.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TUA1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi74 – 829"HIGH" region
    Motifi321 – 3255"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.
    OMAiSIYHRFM.
    PhylomeDBiQ8TUA1.

    Family and domain databases

    Gene3Di3.40.50.620. 2 hits.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 2 hits.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.

    Sequencei

    Sequence statusi: Complete.

    Q8TUA1-1 [UniParc]FASTAAdd to Basket

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    MDTKLDPWSS SDITDYSKLF EEFGISPFEN VLPEIPSPHM YMRRKVIFGH    50
    RDYEQIAEAM RTGAPFSVMD GFMPSGKVHL GHKMVMDQIV WHQEMGASAF 100
    VGIADREAFS VRGFSWQKCR EIGVEEYILS LIALGFKPDG LIYFQSGCGS 150
    VKDLAFELGA KVNFSELSAI YGFSGETSLS HMLSVATQAA DILQPQLEEF 200
    GGPKPVVVPV GPDQDPHLRL TRGLAGKMNM FRVEEREDVK TGRKYLSVRG 250
    KTAQKEALQE LKKRIPGKVK LYEEHIDVLE YPDLAGLEKL VREVTVEFGG 300
    YAFIPPASTY HRFMSGLQGG KMSSSIPESQ IALTDSPKEG AKKVKRAKTG 350
    GCVTLEEQKK LGGKPEECSV FELMLFHLIA SDEELLEIKQ ECISGTRMCG 400
    SCKQLAAEKM QEFLKDHQEK RELAREHLDE YRIIYKD 437
    Length:437
    Mass (Da):49,067
    Last modified:June 1, 2002 - v1
    Checksum:i10DF8FBBBFE7A365
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM03625.1.
    RefSeqiNP_615145.1. NC_003552.1.
    WP_011020230.1. NC_003552.1.

    Genome annotation databases

    EnsemblBacteriaiAAM03625; AAM03625; MA_0172.
    GeneIDi1472064.
    KEGGimac:MA0172.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM03625.1 .
    RefSeqi NP_615145.1. NC_003552.1.
    WP_011020230.1. NC_003552.1.

    3D structure databases

    ProteinModelPortali Q8TUA1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 188937.MA0172.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM03625 ; AAM03625 ; MA_0172 .
    GeneIDi 1472064.
    KEGGi mac:MA0172.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.
    OMAi SIYHRFM.
    PhylomeDBi Q8TUA1.

    Enzyme and pathway databases

    BioCyci MACE188937:GI2O-173-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 2 hits.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 2 hits.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
      Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
      , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
      Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

    Entry informationi

    Entry nameiSYW_METAC
    AccessioniPrimary (citable) accession number: Q8TUA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3