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Q8TUA1

- SYW_METAC

UniProt

Q8TUA1 - SYW_METAC

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMACE188937:GI2O-173-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MA_0172
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Tryptophan--tRNA ligasePRO_0000136722Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi188937.MA0172.

Structurei

3D structure databases

ProteinModelPortaliQ8TUA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi74 – 829"HIGH" region
Motifi321 – 3255"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
InParanoidiQ8TUA1.
KOiK01867.
OMAiSIYHRFM.
PhylomeDBiQ8TUA1.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.

Sequencei

Sequence statusi: Complete.

Q8TUA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTKLDPWSS SDITDYSKLF EEFGISPFEN VLPEIPSPHM YMRRKVIFGH
60 70 80 90 100
RDYEQIAEAM RTGAPFSVMD GFMPSGKVHL GHKMVMDQIV WHQEMGASAF
110 120 130 140 150
VGIADREAFS VRGFSWQKCR EIGVEEYILS LIALGFKPDG LIYFQSGCGS
160 170 180 190 200
VKDLAFELGA KVNFSELSAI YGFSGETSLS HMLSVATQAA DILQPQLEEF
210 220 230 240 250
GGPKPVVVPV GPDQDPHLRL TRGLAGKMNM FRVEEREDVK TGRKYLSVRG
260 270 280 290 300
KTAQKEALQE LKKRIPGKVK LYEEHIDVLE YPDLAGLEKL VREVTVEFGG
310 320 330 340 350
YAFIPPASTY HRFMSGLQGG KMSSSIPESQ IALTDSPKEG AKKVKRAKTG
360 370 380 390 400
GCVTLEEQKK LGGKPEECSV FELMLFHLIA SDEELLEIKQ ECISGTRMCG
410 420 430
SCKQLAAEKM QEFLKDHQEK RELAREHLDE YRIIYKD
Length:437
Mass (Da):49,067
Last modified:June 1, 2002 - v1
Checksum:i10DF8FBBBFE7A365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM03625.1.
RefSeqiNP_615145.1. NC_003552.1.
WP_011020230.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM03625; AAM03625; MA_0172.
GeneIDi1472064.
KEGGimac:MA0172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM03625.1 .
RefSeqi NP_615145.1. NC_003552.1.
WP_011020230.1. NC_003552.1.

3D structure databases

ProteinModelPortali Q8TUA1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 188937.MA0172.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM03625 ; AAM03625 ; MA_0172 .
GeneIDi 1472064.
KEGGi mac:MA0172.

Phylogenomic databases

eggNOGi COG0180.
InParanoidi Q8TUA1.
KOi K01867.
OMAi SIYHRFM.
PhylomeDBi Q8TUA1.

Enzyme and pathway databases

BioCyci MACE188937:GI2O-173-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 2 hits.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Entry informationi

Entry nameiSYW_METAC
AccessioniPrimary (citable) accession number: Q8TUA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3