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Q8TUA1 (SYW_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:MA_0172
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136722

Regions

Motif74 – 829"HIGH" region HAMAP-Rule MF_00140
Motif321 – 3255"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
Q8TUA1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 10DF8FBBBFE7A365

FASTA43749,067
        10         20         30         40         50         60 
MDTKLDPWSS SDITDYSKLF EEFGISPFEN VLPEIPSPHM YMRRKVIFGH RDYEQIAEAM 

        70         80         90        100        110        120 
RTGAPFSVMD GFMPSGKVHL GHKMVMDQIV WHQEMGASAF VGIADREAFS VRGFSWQKCR 

       130        140        150        160        170        180 
EIGVEEYILS LIALGFKPDG LIYFQSGCGS VKDLAFELGA KVNFSELSAI YGFSGETSLS 

       190        200        210        220        230        240 
HMLSVATQAA DILQPQLEEF GGPKPVVVPV GPDQDPHLRL TRGLAGKMNM FRVEEREDVK 

       250        260        270        280        290        300 
TGRKYLSVRG KTAQKEALQE LKKRIPGKVK LYEEHIDVLE YPDLAGLEKL VREVTVEFGG 

       310        320        330        340        350        360 
YAFIPPASTY HRFMSGLQGG KMSSSIPESQ IALTDSPKEG AKKVKRAKTG GCVTLEEQKK 

       370        380        390        400        410        420 
LGGKPEECSV FELMLFHLIA SDEELLEIKQ ECISGTRMCG SCKQLAAEKM QEFLKDHQEK 

       430 
RELAREHLDE YRIIYKD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM03625.1.
RefSeqNP_615145.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TUA1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA0172.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM03625; AAM03625; MA_0172.
GeneID1472064.
KEGGmac:MA0172.

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMASIYHRFM.
PhylomeDBQ8TUA1.
ProtClustDBPRK12285.

Enzyme and pathway databases

BioCycMACE188937:GI2O-173-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 2 hits.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
ProtoNetSearch...

Entry information

Entry nameSYW_METAC
AccessionPrimary (citable) accession number: Q8TUA1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries