Reviewed,
UniProtKB/Swiss-Prot Q8TTZ9 (MTRE_METAC)
Last modified
June 16, 2009.
Version 43.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tetrahydromethanopterin S-methyltransferase subunit E EC=2.1.1.86 Alternative name(s): N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E | ||||
| Gene names |
| ||||
| Organism | Methanosarcina acetivorans [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2214 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina |
Protein attributes
| Sequence length | 304 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step By similarity. |
| Catalytic activity | 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. HAMAP MF_01098 |
| Pathway | One-carbon metabolism; methanogenesis from carbone dioxide; methyl-CoM from 5,10-methylene-H(4)MPT: step 2/2. HAMAP MF_01098 |
| Subunit structure | The complex is composed of 8 subunits; mtrA, mtrB, mtrC, mtrD, mtrE, mtrF, mtrG and mtrH By similarity. |
| Subcellular location | Cell membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Belongs to the mtrE family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Methanogenesis One-carbon metabolism |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transportInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro integral to membraneInferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell vesicle membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | tetrahydromethanopterin S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 304 | 304 | Tetrahydromethanopterin S-methyltransferase subunit E HAMAP MF_01098 | PRO_0000147536 | |||||
Regions | |||||||||
| Transmembrane | 3 – 23 | 21 | Potential | ||||||
| Transmembrane | 86 – 106 | 21 | Potential | ||||||
| Transmembrane | 131 – 151 | 21 | Potential | ||||||
| Transmembrane | 152 – 172 | 21 | Potential | ||||||
| Transmembrane | 233 – 253 | 21 | Potential | ||||||
| Transmembrane | 263 – 283 | 21 | Potential | ||||||
Sequences
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References
| [1] | "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. Birren B.Genome Res. 12:532-542(2002) [PubMed: 11932238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A. |
Cross-references
Sequence databases | |
|---|---|
| AE010299 Genomic DNA. Translation: AAM03729.1. | |
| RefSeq | NP_615249.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1472168. |
| GenomeReviews | Gene locus MA_0276 in contig AE010299_GR. |
| KEGG | mac:MA0276. |
| NMPDR | fig|188937.1.peg.275. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8TTZ9. |
| OMA | Q8TTZ9. SNPNSQV. |
Enzyme and pathway databases | |
| BioCyc | MACE188937:MA0276-MON. |
| BRENDA | 2.1.1.86. 275708. |
Family and domain databases | |
| HAMAP | MF_01098. [Tree] |
| InterPro | IPR005780. MeTrfase_E. [Graphical view] |
| Pfam | PF04206. MtrE. 1 hit. [Graphical view] |
| PIRSF | PIRSF016509. MtrE. 1 hit. |
| TIGRFAMs | TIGR01113. mtrE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MTRE_METAC | ||||||||
| Accession | Primary (citable) accession number: Q8TTZ9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


