Q8TTZ9 (MTRE_METAC) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 60.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tetrahydromethanopterin S-methyltransferase subunit E EC=2.1.1.86 Alternative name(s): N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E | ||||
| Gene names |
| ||||
| Organism | Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) | ||||
| Taxonomic identifier | 188937 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina |
Protein attributes
| Sequence length | 304 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step By similarity. HAMAP MF_01098 |
| Catalytic activity | 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. HAMAP MF_01098 |
| Pathway | One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. HAMAP MF_01098 |
| Subunit structure | The complex is composed of 8 subunits; mtrA, mtrB, mtrC, mtrD, mtrE, mtrF, mtrG and mtrH By similarity. |
| Subcellular location | Cell membrane; Multi-pass membrane protein Potential HAMAP MF_01098. |
| Sequence similarities | Belongs to the mtrE family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Methanogenesis One-carbon metabolism |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transportInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro integral to membraneInferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell vesicle membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | tetrahydromethanopterin S-methyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 304 | 304 | Tetrahydromethanopterin S-methyltransferase subunit E HAMAP MF_01098 | PRO_0000147536 | |||||
Regions | |||||||||
| Transmembrane | 3 – 23 | 21 | Helical; Potential | ||||||
| Transmembrane | 86 – 106 | 21 | Helical; Potential | ||||||
| Transmembrane | 131 – 151 | 21 | Helical; Potential | ||||||
| Transmembrane | 152 – 172 | 21 | Helical; Potential | ||||||
| Transmembrane | 233 – 253 | 21 | Helical; Potential | ||||||
| Transmembrane | 263 – 283 | 21 | Helical; Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. Birren B.Genome Res. 12:532-542(2002) [PubMed: 11932238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE010299 Genomic DNA. Translation: AAM03729.1. |
| RefSeq | NP_615249.1. NC_003552.1. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1472168. |
| GenomeReviews | Gene locus MA_0276 in contig AE010299_GR. |
| KEGG | mac:MA0276. |
| NMPDR | fig|188937.1.peg.275. |
Phylogenomic databases | |
| HOGENOM | HBG539646. |
| OMA | SNPNSQV. |
| ProtClustDB | PRK00972. |
Enzyme and pathway databases | |
| BioCyc | MACE188937:MA0276-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01098. MtrE. [Tree] |
| InterPro | IPR005780. MeTrfase_E. [Graphical view] |
| KO | K00581. |
| Pfam | PF04206. MtrE. 1 hit. [Graphical view] |
| PIRSF | PIRSF016509. MtrE. 1 hit. |
| TIGRFAMs | TIGR01113. MtrE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MTRE_METAC | ||||||||
| Accession | Primary (citable) accession number: Q8TTZ9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with