Q8TTA5 (MTBB1_METAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dimethylamine methyltransferase MtbB1
Short name=DMA methyltransferase 1
Short name=DMAMT 1
EC=2.1.1.249

Alternative name(s):
Dimethylamine--corrinoid protein methyltransferase 1

Gene names

Name:	mtbB1
Ordered Locus Names:	MA_0532

Organism

Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]

Taxonomic identifier

188937 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina acetivorans

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of MtbC By similarity.
Catalytic activity	Dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] = a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine.
Pathway	One-carbon metabolism; methanogenesis from dimethylamine.
Sequence similarities	Belongs to the dimethylamine methyltransferase family.

Ontologies

Keywords
Biological process	Methanogenesis
Coding sequence diversity	Pyrrolysine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Dimethylamine methyltransferase MtbB1		PRO_0000216563
Amino acid modifications
	Non-standard residue	356	1	Pyrrolysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TTA5 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: CC21E7D0E420CEF1	FASTA	467	50,392
	10 20 30 40 50 60 MATEYALRMG DGKRVFLTKE KILEELEAGM ANASDLGEIP DLSADEIDKL AEILMMPGKA 70 80 90 100 110 120 VSVEQGMEVP VTHDIGTIRL DGDQGNSGVG IPSSRLVGCM THERAFGADT MELGHIDYSF 130 140 150 160 170 180 KPVKPVVSNE CQAMEVCQQN MIIPLFYGAM PNMGLYYTPD GPFENPGDLM KAFKIQEAWE 190 200 210 220 230 240 SMEHAAEHLT RDTVWVMQKL FASGTDGVNF DTTAAAGDAD MYGTLHAIEA LRKEFPDMYI 250 260 270 280 290 300 EAGMAGECVL GMHGNLQYDG VTLAGLWPHQ QAPLVAKAGA NVFGPVCNTN TSKTSAWNLA 310 320 330 340 350 360 RAVNFMKAAV QASPIPCHVD MGMGVGGIPM LETPPVDAVT RASKAMVEVA GVDGIOIGVG 370 380 390 400 410 420 DPLGMPISHI MASGMTGIRA AGDLVARMQF SKNMRIGEAK EYVAKKLNVD VMDLADEHVM 430 440 450 460 RELREELDIG VITSVPGAAK GIAAKMNIEK LLDIKINSCN LFRKQIQ

References

[1]

"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B. Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE010299 Genomic DNA. Translation: AAM03976.1.
RefSeq	NP_615496.1. NC_003552.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	188937.MA0532.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM03976; AAM03976; MA_0532.
GeneID	1472424.
KEGG	mac:MA0532.
Phylogenomic databases
eggNOG	NOG71728.
KO	K16178.
OMA	FGPVCNT.
ProtClustDB	CLSK258720.
Enzyme and pathway databases
BioCyc	MACE188937:GI2O-599-MONOMER.
UniPathway	UPA00644.
Family and domain databases
InterPro	IPR012653. Dimeth_MeTrfase_PyL. [Graphical view]
Pfam	PF09505. Dimeth_Pyl. 1 hit. [Graphical view]
TIGRFAMs	TIGR02368. dimeth_PyL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTBB1_METAC

Accession

Primary (citable) accession number: Q8TTA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 55 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program