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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-617-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:MA_0581
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001204811 – 424Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ8TT57

Interactioni

Protein-protein interaction databases

STRINGi188937.MA0581

Structurei

3D structure databases

ProteinModelPortaliQ8TT57
SMRiQ8TT57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00918 Archaea
COG0001 LUCA
InParanoidiQ8TT57
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG093Z024H
PhylomeDBiQ8TT57

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TT57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSEVTLDKS RQMYEKAKTL IPGGVSSPVR AIKPYPFYTA SADGSKIRDL
60 70 80 90 100
DGNEYIDYCL AYGPAVLGHN HPVIKAAIKE QLDKGWLYGT PTELEVTLAE
110 120 130 140 150
KVAGYYPSID MLRFVSTGTE ATMSALRLAR GFTRKNKFIK IEGGFHGAHD
160 170 180 190 200
AVLVKAGSGA TTLGEPDSLG IPADFTKYTL QAPYNDIETM TTLVEKNRDD
210 220 230 240 250
LAAVIIEPVL GNIGPILPLP GYLKELRKLT KENDVLLIFD EVITGFRLAM
260 270 280 290 300
GGAQEYFGVV PDMTTLGKIV GGGLPIGVFG GRREIMEMIA PSGAVYQAGT
310 320 330 340 350
FSGSPCSVAA GIAVLDYLKK EDIHAKLNST GDYMRAVVSE IVEDEGLDYT
360 370 380 390 400
VCGIASMFKI FFGAEPHNYQ EALKCDKEGY LSFFHRMLAN GVFLPPSQFE
410 420
TNFISAAHSE EDIEKTLEAY VENL
Length:424
Mass (Da):46,147
Last modified:June 1, 2002 - v1
Checksum:iC95F959EAE0DB6A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM04025.1
RefSeqiWP_011020630.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM04025; AAM04025; MA_0581
GeneIDi1472473
KEGGimac:MA_0581

Similar proteinsi

Entry informationi

Entry nameiGSA_METAC
AccessioniPrimary (citable) accession number: Q8TT57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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