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Q8TT57 (GSA_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate-1-semialdehyde 2,1-aminomutase

Short name=GSA
EC=5.4.3.8
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT
Gene names
Name:hemL
Ordered Locus Names:MA_0581
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutamate-1-semialdehyde 2,1-aminomutase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

transaminase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375
PRO_0000120481

Amino acid modifications

Modified residue2681N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TT57 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: C95F959EAE0DB6A9

FASTA42446,147
        10         20         30         40         50         60 
MVSEVTLDKS RQMYEKAKTL IPGGVSSPVR AIKPYPFYTA SADGSKIRDL DGNEYIDYCL 

        70         80         90        100        110        120 
AYGPAVLGHN HPVIKAAIKE QLDKGWLYGT PTELEVTLAE KVAGYYPSID MLRFVSTGTE 

       130        140        150        160        170        180 
ATMSALRLAR GFTRKNKFIK IEGGFHGAHD AVLVKAGSGA TTLGEPDSLG IPADFTKYTL 

       190        200        210        220        230        240 
QAPYNDIETM TTLVEKNRDD LAAVIIEPVL GNIGPILPLP GYLKELRKLT KENDVLLIFD 

       250        260        270        280        290        300 
EVITGFRLAM GGAQEYFGVV PDMTTLGKIV GGGLPIGVFG GRREIMEMIA PSGAVYQAGT 

       310        320        330        340        350        360 
FSGSPCSVAA GIAVLDYLKK EDIHAKLNST GDYMRAVVSE IVEDEGLDYT VCGIASMFKI 

       370        380        390        400        410        420 
FFGAEPHNYQ EALKCDKEGY LSFFHRMLAN GVFLPPSQFE TNFISAAHSE EDIEKTLEAY 


VENL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM04025.1.
RefSeqNP_615545.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TT57.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA0581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM04025; AAM04025; MA_0581.
GeneID1472473.
KEGGmac:MA0581.

Phylogenomic databases

eggNOGCOG0001.
KOK01845.
OMACSWGPLI.
PhylomeDBQ8TT57.
ProtClustDBPRK00062.

Enzyme and pathway databases

BioCycMACE188937:GI2O-587-MONOMER.
UniPathwayUPA00251; UER00317.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00375. HemL_aminotrans_3.
InterProIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00713. hemL. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSA_METAC
AccessionPrimary (citable) accession number: Q8TT57
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways