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Protein

Exosome complex component Csl4

Gene

csl4

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi275 – 2751ZincUniRule annotation
Metal bindingi278 – 2781ZincUniRule annotation
Metal bindingi291 – 2911ZincUniRule annotation
Metal bindingi294 – 2941ZincUniRule annotation

GO - Molecular functioni

  1. RNA binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMACE188937:GI2O-731-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component Csl4UniRule annotation
Gene namesi
Name:csl4UniRule annotation
Ordered Locus Names:MA_0720Imported
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)Imported
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. exosome (RNase complex) Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, ExosomeUniRule annotation

Interactioni

Subunit structurei

Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.UniRule annotation

Protein-protein interaction databases

STRINGi188937.MA0720.

Structurei

3D structure databases

ProteinModelPortaliQ8TSS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 26679S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CSL4 family.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1096.
InParanoidiQ8TSS5.
KOiK07573.
OMAiSRDQFKG.
PhylomeDBiQ8TSS5.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00975. Exosome_Csl4.
InterProiIPR019495. EXOSC1.
IPR025721. Exosome_cplx_N_dom.
IPR030850. Exosome_Csl4_arc.
IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. S1_dom.
[Graphical view]
PfamiPF14382. ECR1_N. 1 hit.
PF10447. EXOSC1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TSS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRIRKNKTT RKKLTGPGEG KPVAEKSVPV AAESREQFKG QPRDQPRDQF
60 70 80 90 100
KGQSRGQSRD QFKGHSRDQF KGQSRGSRDQ SKDQFKGDLG KKRRFPYSKK
110 120 130 140 150
SPRDRKEIPG FRPPAREPVR SEEDLEKGGF VLPGELVGTT EEFKSGAGTT
160 170 180 190 200
VIGGDIYSTA TGNVLIDRKS RVVSVKPNTL TPNILKVGDI VYGKITDVRE
210 220 230 240 250
SGAMVEVAGI EGKENREIVN TRPGDIHVSN VRDSYVKRLS DEFRPSDIVK
260 270 280 290 300
ARVIDVDRMR LTTSEDSLGV VKAYCSNCRG ELVLEGKKLK CPVCNMTETR
310
KISTEYGKGI R
Length:311
Mass (Da):34,656
Last modified:June 1, 2002 - v1
Checksum:i3E98EA5833355F8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM04160.1.
RefSeqiNP_615680.1. NC_003552.1.
WP_011020765.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM04160; AAM04160; MA_0720.
GeneIDi1472612.
KEGGimac:MA0720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM04160.1.
RefSeqiNP_615680.1. NC_003552.1.
WP_011020765.1. NC_003552.1.

3D structure databases

ProteinModelPortaliQ8TSS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi188937.MA0720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM04160; AAM04160; MA_0720.
GeneIDi1472612.
KEGGimac:MA0720.

Phylogenomic databases

eggNOGiCOG1096.
InParanoidiQ8TSS5.
KOiK07573.
OMAiSRDQFKG.
PhylomeDBiQ8TSS5.

Enzyme and pathway databases

BioCyciMACE188937:GI2O-731-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00975. Exosome_Csl4.
InterProiIPR019495. EXOSC1.
IPR025721. Exosome_cplx_N_dom.
IPR030850. Exosome_Csl4_arc.
IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. S1_dom.
[Graphical view]
PfamiPF14382. ECR1_N. 1 hit.
PF10447. EXOSC1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C., Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2AImported.

Entry informationi

Entry nameiQ8TSS5_METAC
AccessioniPrimary (citable) accession number: Q8TSS5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 29, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.