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Protein

DNA ligase 1

Gene

lig1

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei245ATPUniRule annotation1
Active sitei247N6-AMP-lysine intermediateUniRule annotation1
Binding sitei252ATPUniRule annotation1
Binding sitei267ATPUniRule annotation1
Binding sitei297ATPUniRule annotation1
Binding sitei343ATPUniRule annotation1
Binding sitei420ATPUniRule annotation1
Binding sitei426ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 1UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 1UniRule annotation
Gene namesi
Name:lig1UniRule annotation
Ordered Locus Names:MA_0728
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652571 – 580DNA ligase 1Add BLAST580

Interactioni

Protein-protein interaction databases

STRINGi188937.MA0728

Structurei

3D structure databases

ProteinModelPortaliQ8TSR7
SMRiQ8TSR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
InParanoidiQ8TSR7
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0
PhylomeDBiQ8TSR7

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TSR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRFKELAEL FEELERITSH KEIVRKLAGF FGGLKGDEVK DSAYLFLGSI
60 70 80 90 100
GPAFENTTLG IKDRLVTRAI AGAYGVSEEE VKKRYARAGD LGDVAFELSK
110 120 130 140 150
KREASLTIEE VFKRLRQIKE ASGKGSQEKK TGLLSDILQK ATPEEGKYII
160 170 180 190 200
RIVLGRLRLG FGDQFLLEAF SIAFTGDKKH AGKIKESYSV CTDIGELAQT
210 220 230 240 250
LAEHGAGAPG YFSIKPGRPV KSMLAQRVES FEELEERIKG KKAAEEKYDG
260 270 280 290 300
ERVQIHKAGD EIKAFSRRLE DITAQYPDII EAVRESISAD TIVLDGEIVA
310 320 330 340 350
YAELEKENTR IEEFYPFQNL MQRRRKYEVE KYREKCPVAV FFFDILYLNG
360 370 380 390 400
ESLLKKTYPE RRALLEEHVN GSGIVHLTRR TVTENIEELE DFFNETVEKG
410 420 430 440 450
LEGIVAKSMS SNSVYEAGKR SWLWLKWKQE YSEGMRETFD LVVVGSYYGK
460 470 480 490 500
GKRKGSFGAL LCAVLNEEEQ QFETFTKVGT GFTEADAEEI NSLLSAHTVS
510 520 530 540 550
EAPKNVIIKK GMLPDIFIEP AVVIEVLGSE ITNSPGHTAG EGEEETGLAL
560 570 580
RFPRFLRIRY DRAPFDATTV REIRDLKEGI
Length:580
Mass (Da):65,351
Last modified:June 1, 2002 - v1
Checksum:i31C511F878C79E73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM04168.1

Genome annotation databases

EnsemblBacteriaiAAM04168; AAM04168; MA_0728
KEGGimac:MA_0728

Similar proteinsi

Entry informationi

Entry nameiDNLI1_METAC
AccessioniPrimary (citable) accession number: Q8TSR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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