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Q8TSR7

- DNLI1_METAC

UniProt

Q8TSR7 - DNLI1_METAC

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Protein
DNA ligase 1
Gene
lig1, MA_0728
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei245 – 2451ATP By similarity
Active sitei247 – 2471N6-AMP-lysine intermediate By similarity
Binding sitei252 – 2521ATP By similarity
Binding sitei267 – 2671ATP By similarity
Binding sitei297 – 2971ATP By similarity
Binding sitei343 – 3431ATP By similarity
Binding sitei420 – 4201ATP By similarity
Binding sitei426 – 4261ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation Source: RefGenome
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
  6. lagging strand elongation Source: RefGenome
  7. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMACE188937:GI2O-739-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 1 (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 1
Gene namesi
Name:lig1
Ordered Locus Names:MA_0728
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580DNA ligase 1UniRule annotation
PRO_0000365257Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi188937.MA0728.

Structurei

3D structure databases

ProteinModelPortaliQ8TSR7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
KOiK10747.
OMAiCTDIGEL.
PhylomeDBiQ8TSR7.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TSR7-1 [UniParc]FASTAAdd to Basket

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MVRFKELAEL FEELERITSH KEIVRKLAGF FGGLKGDEVK DSAYLFLGSI    50
GPAFENTTLG IKDRLVTRAI AGAYGVSEEE VKKRYARAGD LGDVAFELSK 100
KREASLTIEE VFKRLRQIKE ASGKGSQEKK TGLLSDILQK ATPEEGKYII 150
RIVLGRLRLG FGDQFLLEAF SIAFTGDKKH AGKIKESYSV CTDIGELAQT 200
LAEHGAGAPG YFSIKPGRPV KSMLAQRVES FEELEERIKG KKAAEEKYDG 250
ERVQIHKAGD EIKAFSRRLE DITAQYPDII EAVRESISAD TIVLDGEIVA 300
YAELEKENTR IEEFYPFQNL MQRRRKYEVE KYREKCPVAV FFFDILYLNG 350
ESLLKKTYPE RRALLEEHVN GSGIVHLTRR TVTENIEELE DFFNETVEKG 400
LEGIVAKSMS SNSVYEAGKR SWLWLKWKQE YSEGMRETFD LVVVGSYYGK 450
GKRKGSFGAL LCAVLNEEEQ QFETFTKVGT GFTEADAEEI NSLLSAHTVS 500
EAPKNVIIKK GMLPDIFIEP AVVIEVLGSE ITNSPGHTAG EGEEETGLAL 550
RFPRFLRIRY DRAPFDATTV REIRDLKEGI 580
Length:580
Mass (Da):65,351
Last modified:June 1, 2002 - v1
Checksum:i31C511F878C79E73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010299 Genomic DNA. Translation: AAM04168.1.
RefSeqiNP_615688.1. NC_003552.1.
WP_011020773.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM04168; AAM04168; MA_0728.
GeneIDi1472620.
KEGGimac:MA0728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010299 Genomic DNA. Translation: AAM04168.1 .
RefSeqi NP_615688.1. NC_003552.1.
WP_011020773.1. NC_003552.1.

3D structure databases

ProteinModelPortali Q8TSR7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 188937.MA0728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM04168 ; AAM04168 ; MA_0728 .
GeneIDi 1472620.
KEGGi mac:MA0728.

Phylogenomic databases

eggNOGi COG1793.
KOi K10747.
OMAi CTDIGEL.
PhylomeDBi Q8TSR7.

Enzyme and pathway databases

BioCyci MACE188937:GI2O-739-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Entry informationi

Entry nameiDNLI1_METAC
AccessioniPrimary (citable) accession number: Q8TSR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3