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Q8TS37 (PYRF_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:MA_0969
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Sequence caution

The sequence AAM04401.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134609

Regions

Region60 – 6910Substrate binding By similarity
Region170 – 18011Substrate binding By similarity

Sites

Active site621Proton donor By similarity
Binding site121Substrate By similarity
Binding site341Substrate By similarity
Binding site1171Substrate By similarity
Binding site1931Substrate; via amide nitrogen By similarity
Binding site1941Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TS37 [UniParc].

Last modified October 10, 2002. Version 2.
Checksum: A3FC8CF97B7CCF75

FASTA22123,762
        10         20         30         40         50         60 
MERNTCMILA LDVTDREEAL KIAEDVWEFV DAIKVGYPLI LATGLGIIRE LAEFAPVIAD 

        70         80         90        100        110        120 
FKVADIPNTN RLICDQVFEA GADAVIAQGF TGRDSLDACI EIASEYRKDV FVVSEMSHPG 

       130        140        150        160        170        180 
GADFMQPVAE AIAKMALEAG AFGLVAPATR PKRVKKIRRI IGDKLTIISP GVGAQGGKAS 

       190        200        210        220 
DVIAAGADWV IVGRSIYKAE SPKEAARQIA EEIQAELRGE Y 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM04401.1. Different initiation.
RefSeqNP_615921.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TS37.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA0969.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM04401; AAM04401; MA_0969.
GeneID1472859.
KEGGmac:MA0969.

Phylogenomic databases

eggNOGCOG0284.
KOK01591.
OMATEMSHPG.
PhylomeDBQ8TS37.

Enzyme and pathway databases

BioCycMACE188937:GI2O-980-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_A. OMPdecase_type1_A.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_METAC
AccessionPrimary (citable) accession number: Q8TS37
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways