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Protein

Ribonuclease P protein component 1

Gene

rnp1

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. mRNA cleavage Source: InterPro
  2. rRNA processing Source: InterPro
  3. tRNA 5'-leader removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciMACE188937:GI2O-1091-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component 1UniRule annotation (EC:3.1.26.5UniRule annotation)
Short name:
RNase P component 1UniRule annotation
Alternative name(s):
Rpp29UniRule annotation
Gene namesi
Name:rnp1UniRule annotation
Ordered Locus Names:MA_1080
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. ribonuclease MRP complex Source: InterPro
  3. ribonuclease P complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 110110Ribonuclease P protein component 1PRO_0000128428Add
BLAST

Interactioni

Subunit structurei

Consists of a catalytic RNA component and at least 4-5 protein subunits.UniRule annotation

Protein-protein interaction databases

STRINGi188937.MA1080.

Structurei

3D structure databases

ProteinModelPortaliQ8TRT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic/archaeal RNase P protein component 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1588.
InParanoidiQ8TRT9.
KOiK03538.
OMAiQPENRIP.
PhylomeDBiQ8TRT9.

Family and domain databases

Gene3Di2.30.30.210. 1 hit.
HAMAPiMF_00754. RNase_P_1.
InterProiIPR002730. RNase_P/MRP_p29.
IPR023538. RNase_P_comp-1.
IPR023534. Rof/RNase_P-like.
[Graphical view]
PfamiPF01868. UPF0086. 1 hit.
[Graphical view]
SUPFAMiSSF101744. SSF101744. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TRT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSKVEILPS NLIFHELIGL EIKVINSTNP SLTGIRGRVI NETKNMLVVE
60 70 80 90 100
NSQSRELKIP KADSEFLFRI PAELSEKGRR SDTFVKIQGN LLLSQPENRI
110
KNIKKLRKWG
Length:110
Mass (Da):12,610
Last modified:May 31, 2002 - v1
Checksum:i86D4F741924C8D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM04505.1.
RefSeqiNP_616025.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM04505; AAM04505; MA_1080.
GeneIDi1472970.
KEGGimac:MA1080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM04505.1.
RefSeqiNP_616025.1. NC_003552.1.

3D structure databases

ProteinModelPortaliQ8TRT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi188937.MA1080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM04505; AAM04505; MA_1080.
GeneIDi1472970.
KEGGimac:MA1080.

Phylogenomic databases

eggNOGiCOG1588.
InParanoidiQ8TRT9.
KOiK03538.
OMAiQPENRIP.
PhylomeDBiQ8TRT9.

Enzyme and pathway databases

BioCyciMACE188937:GI2O-1091-MONOMER.

Family and domain databases

Gene3Di2.30.30.210. 1 hit.
HAMAPiMF_00754. RNase_P_1.
InterProiIPR002730. RNase_P/MRP_p29.
IPR023538. RNase_P_comp-1.
IPR023534. Rof/RNase_P-like.
[Graphical view]
PfamiPF01868. UPF0086. 1 hit.
[Graphical view]
SUPFAMiSSF101744. SSF101744. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Entry informationi

Entry nameiRNP1_METAC
AccessioniPrimary (citable) accession number: Q8TRT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2004
Last sequence update: May 31, 2002
Last modified: January 6, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.